Results 121 to 130 of about 3,440,012 (315)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Using underapproximations for sparse nonnegative matrix factorization [PDF]
Nonnegative Matrix Factorization (NMF) has gathered a lot of attention in the last decade and has been successfully applied in numerous applications.
GILLIS, Nicolas, GLINEUR, François
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Damage-programmable design of metamaterials achieving crack-resisting mechanisms seen in nature
Nature CommunicationsThe fracture behaviour of artificial metamaterials often leads to catastrophic failures with limited resistance to crack propagation. In contrast, natural materials such as bones and ceramics possess microstructures that give rise to spatially ...
Zhenyang Gao +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Moving the Matrix: kinesics, space and embodiment in the Matrix trilogy [PDF]
, 2005 The Matrix (1999) is movement, establishing the kinesics that characterise the trilogy generally and make their viewing a breathtaking experience.
Cranny-Francis, A
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Разработка и регистрация лекарственных средств, 2019 Clinical study report is one of the main documents during the drug development. The preparation of the clinical study report requires knowledge of Russian and foreign legislation, awareness of guidelines and recommendatioins issued by the professional ...
E. A. Radkova +3 more
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
SINGULAR RANDOM MATRIX DECOMPOSITIONS: DISTRIBUTIONS. [PDF]
Assuming that Y has a singular matrix variate elliptically contoured distribution with respect to the Hausdorff measure, the distributions of several matrices associated to QR, modified QR, SV and Polar decompositions of matrix Y are determined, for ...
Graciela González-Farías +1 more
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The matrix completion problem [PDF]
, 2011 Nowadays, the relevant amount of information exchanges force the experts to create more reliable, secure and error-less devices through which these can happen.
Nalin, Gianmarco
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