Results 131 to 140 of about 3,440,012 (315)

Matrix-assisted DOSY [PDF]

, 2019
The analysis of mixtures by NMR spectroscopy is challenging. Diffusion-ordered NMR spectroscopy enables a pseudo-separation of species based on differences in their translational diffusion coefficients.
Iain Day (4462090)
core   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Local, Controlled Release In Vivo of Vascular Endothelial Growth Factor Within a Subcutaneous Scaffolded Islet Implant Reduces Early Islet Necrosis and Improves Performance of the Graft

Cell Transplantation, 2018
Islet transplantation remains the only alternative to daily insulin therapy for control of type 1 diabetes (T1D) in humans. To avoid the drawbacks of intrahepatic islet transplantation, we are developing a scaffolded islet implant to transplant islets ...
John A. Gebe, Anton Preisinger, Michel D. Gooden, Leonard A. D’Amico, Robert B. Vernon   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Grewia polysaccharide as a pharmaceutical excipient in matrix tablets [PDF]

, 2011
Matrix-based tablets using different concentrations of grewia gum, and the model drug ibuprofen, were prepared using a wet granulation technique. Similar formulations were also prepared using HPMC, guar gum or ethyl cellulose as the polymer matrix.
Conway, Barbara R, Barbara R. Conway, Nep, Elijah I., Nep, E.I., Conway, Barbara R., Elijah I. Nep   +5 more
core  

Combined Matrix of a Tridiagonal Toeplitz Matrix

Axioms
In this work, combined matrices of tridiagonal Toeplitz matrices are studied. The combined matrix is known as the Relative Gain Array in control theory. In particular, given a real tridiagonal Toeplitz matrix of order n, the characterization of its combined matrix as a bisymmetric and doubly quasi-stochastic matrix is studied.
Begoña Cantó, Rafael Cantó, Ana Maria Urbano   +2 more
openaire   +3 more sources

Channel matrix, measurement matrix and collapsed matrix in teleportation

, 2014
In this paper, two kinds of coefficient matrixes (channel matrix, measurement matrix)associated with the pure state for teleportation are presented, the general relation among channel matrix, measurement matrix and collapsed matrix is obtained. In addition, a criterion for teleportation that the number of coefficient of an unknown state is determined ...
Zha, Xin-Wei, Qi, Jian-Xia, Song, Hai-Yang   +2 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

SIAM J. Matrix Analysis Appl [PDF]

, 2013
The SIAM Journal on Matrix Analysis and Applications publishes research articles in matrix analysis and its applications and papers of interest to the numerical linear algebra community.
SIMONCINI, VALERIA
core  

Optimizing degassing for particle-reinforced Al composite: Advanced ultrasonic-assisted argon treatment and numerical simulation insights

Ultrasonics Sonochemistry
Hydrogen removal from particle-reinforced Al composite is critical for preventing porosities near particle clusters and improving comprehensive material properties.
Jian Chen, Xinyuan Jin, Jiwei Geng, Xianhui Luo, Yugang Li, Peikang Xia, Xianfeng Li, Fangming Wang, Dong Chen, Mingliang Wang, Haowei Wang   +10 more
doaj   +1 more source