Results 41 to 50 of about 42,588 (304)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

A semismooth newton method for the nearest Euclidean distance matrix problem

open access: yes, 2013
The Nearest Euclidean distance matrix problem (NEDM) is a fundamentalcomputational problem in applications such asmultidimensional scaling and molecularconformation from nuclear magnetic resonance data in computational chemistry.Especially in the latter ...
Qi, Houduo
core   +1 more source

Methodology of optimization of territorially-branch structure of region in the conditions of economy reforming [PDF]

open access: yesЭкономика региона, 2012
This paper is devoted to the analysis of transition from centralized planning economy to market relations, revealing of problems and working out of necessary macro proportions in placing of productive forces, integration maintenance between ...
Arkadiy Iosifovich Moroz
doaj   +1 more source

Dynamic Tensor Modeling for Missing Data Completion in Electronic Toll Collection Gantry Systems

open access: yesSensors, 2023
The deployment of Electronic Toll Collection (ETC) gantry systems marks a transformative advancement in the journey toward an interconnected and intelligent highway traffic infrastructure.
Yikang Rui, Yan Zhao, Wenqi Lu, Can Wang
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

The (weakly) sign symmetric P-matrix completion problems

open access: yes, 2003
In this paper it is shown that a partial sign symmetric P-matrix, whose digraph of specified entries is a symmetric n-cycle with n ≥ 6, can be completed to a sign symmetric P-matrix.
Hardy, Timothy L.   +5 more
core   +1 more source

Shaping Intensities of Complex Scalar Fields in Inhomogeneous Scenarios via Linearly Combined Bricks

open access: yesIEEE Open Journal of Antennas and Propagation
The ability to enforce a given behaviour on the electromagnetic field intensity distribution is relevant in a wide range of applications, including the particularly challenging case where shaping is required in heterogeneous media.
Martina Teresa Bevacqua   +2 more
doaj   +1 more source

Parameterized Algorithms for the Matrix Completion Problem

open access: yesCoRR, 2018
We consider two matrix completion problems, in which we are given a matrix with missing entries and the task is to complete the matrix in a way that (1) minimizes the rank, or (2) minimizes the number of distinct rows. We study the parameterized complexity of the two aforementioned problems with respect to several parameters of interest, including the ...
Ganian, R.   +3 more
openaire   +4 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Correntropy Based Matrix Completion

open access: yesEntropy, 2018
This paper studies the matrix completion problems when the entries are contaminated by non-Gaussian noise or outliers. The proposed approach employs a nonconvex loss function induced by the maximum correntropy criterion.
Yuning Yang   +2 more
doaj   +1 more source

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