Results 51 to 60 of about 1,862,767 (300)

Two-Phase Two-Stage HF Matrix Converter for Supplying Two-Phase Motor Load

, 2013
This paper deals with the two-stage two-phase electronic systems with orthogonal output voltages and currents - DC/HF_AC/2AC. It also introduces the design and prototype of two-stage DC/HF_AC/2AC high frequency converter with two-phase orthogonal output ...
Michal Prazenica, Michal Kabasta, Jozef Buday, Slavomir Kascak, Juraj Koscelnik   +4 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Direct Matrix Converter Topologies with Model Predictive Current Control Applied as Power Interfaces in AC, DC, and Hybrid Microgrids in Islanded and Grid-Connected Modes

Energies, 2019
This paper presents an analysis of a new application of different direct matrix converter topologies used as power interfaces in AC, DC, and hybrid microgrids, with model predictive current control.
Gustavo Gontijo, Matheus Soares, Thiago Tricarico, Robson Dias, Mauricio Aredes, Josep Guerrero   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Watkins-Johnson converter completes tapped inductor converter matrix

, 2003
The Watkins-Johnson converter has been identified as belonging to the tapped inductor converter families extending once more the matrix of DC-DC converter topologies.
Grant, DA, Darroman, Y
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Dynamic inverse controller with Matrix Converter Drive Feed Three Phase Induction Motor

MATEC Web of Conferences, 2018
Dynamic inversion (DI) is a controller technique by which existing undesirable dynamics are cancelled out and changed by desirable dynamics. The application of induction motor drives with sinusoidal input currents a matrix converter combined with DI is ...
Keream Settar S, Abdalla Ahmed N, Daud Mohd Razali Bin, Koh Johnny   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A review of Indirect Matrix Converter Topologies [PDF]

, 2015
—Matrix Converter (MC) is a modern direct AC/AC electrical power converter without dc-link capacitor. MC is operated in four quadrant, assuring a control of the output voltage, amplitude and frequency.
Salem Rahmani, Lazhar Rmili, Kamal Al-Haddad   +2 more
core   +1 more source