Results 81 to 90 of about 118,710 (298)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Керування машиною подвійного живлення з матричним перетворювачем в колі ротора при несиметрії напруг мережі живлення [PDF]

, 2013
Control algorithms of doubly-fed induction generator with matrix converter under unbalanced grid voltages have been considered. Comparison of the strategies to improve the performance of DFIGs under unbalanced network conditions suggests that some ...
Дорошенко, Андрій Леонідович, Михальський, Валерій Михайлович, Соболєв, Володимир Миколайович, Чопик, Василь Васильович, Шаповал, Іван Андрійович   +4 more
core  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Prospects for terahertz imaging the human skin cancer with the help of gold-nanoparticles-based terahertz-to-infrared converter

, 2019
The design is suggested, and possible operation parameters are discussed, of an instrument to inspect a skin cancer tumour in the terahertz (THz) range, transferring the image into the infrared (IR) and making it visible with the help of standard IR ...
A. G. Paulish, AS Darling, AV Postnikov, AV Postnikov, B. B. Hu, B. Lesiak, C Loo, Cecilie Ro/nne, CL Huang, DALI, E Pickwell, Elizabeth Berry, H Okamoto, I ELSAYED, J. W. Lynn, JH Chen, JH Son, K Moldosanov, KA Moldosanov, KA Moldosanov, KFA Ross, N. E. Christensen, NW Ashcroft, PS Zagubisalo, R Kubo, R. KUBO, RM Woodward, RM Woodward, RM Woodward, S.-J. Oh, SA Kuznetsov, SA Kuznetsov, Sergei Alexandrovich Kuznetsov, Sergey A. Kuznetsov, Seung Jae Oh, Seung Jae Oh, SJ Oh, T Rowland, Tschang-Uh Nahm, V.P. Wallace, VP Wallace, X Huang, Yu. Ya. Gafner, ZM Zhang   +43 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

ZVZCS PWM DC-DC Converter with Energy Recovery Clamp

Advances in Electrical and Electronic Engineering, 2008
This paper presents research motivated by industrial demand for special traction drive topology devoted tominimization of traction transformer weight against topology with classical 50Hz traction transformer.
Jaroslav Durdik, Vladimir Ruscin
doaj  

Gradient System Modelling of Matrix Converters with Input and Output Filters [PDF]

, 2003
Due to its complexity, the dynamics of matrix converters are usually neglected in controller design. However, increasing demands on reduced harmonic generation and higher bandwidths makes it necessary to study large-signal dynamics. A unified methodology
Jeltsema, Dimitri,, Klaassens, J. Ben,, Scherpen, Jacquelien M.A.,   +2 more
core   +1 more source