Results 41 to 50 of about 127,181 (241)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Equations of motion as constraints: superselection rules, Ward identities

Journal of High Energy Physics, 2017
The meaning of local observables is poorly understood in gauge theories, not to speak of quantum gravity. As a step towards a better understanding we study asymptotic (infrared) transformations in local quantum physics.
M. Asorey, A. P. Balachandran, F. Lizzi, G. Marmo   +3 more
doaj   +1 more source

$K \to \pi \pi$ Decays with Domain Wall Fermions: Towards Physical Results

, 2000
We are using domain wall fermions to study $K \to \pi \pi$ matrix elements by measuring $K \to \pi$ and $K \to 0$ matrix elements on the lattice and employing chiral perturbation theory to relate these to the desired physical result.
Bernard, Ciuchini, Furman, Kaplan, Maiani, Martinelli, Robert D. Mawhinney, Shamir, Sharpe   +8 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Some Properties of Generalized Apostol-Type Frobenius–Euler–Fibonacci Polynomials

Mathematics
In this paper, by using the Golden Calculus, we introduce the generalized Apostol-type Frobenius–Euler–Fibonacci polynomials and numbers; additionally, we obtain various fundamental identities and properties associated with these polynomials and numbers,
Maryam Salem Alatawi, Waseem Ahmad Khan, Can Kızılateş, Cheon Seoung Ryoo   +3 more
doaj   +1 more source

DEFT: a program for operators in EFT

Journal of High Energy Physics, 2019
We describe a Python-based computer program, DEFT, for manipulating operators in effective field theories (EFTs). In its current incarnation, DEFT can be applied to 4-dimensional, Poincaré invariant theories with gauge group SU(3) × SU(2) × U(1), such as
Ben Gripaios, Dave Sutherland
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Power of Supersymmetry in D-particle Dynamics [PDF]

, 2002
A new systematic method is developed to study to what extent the symmetry requirements alone, above all the invariance under 16 supersymmetries (SUSY), determine the completely off-shell effective action $\Gamma$ of a D-particle, i.e.
Aharony, Baake, Banks, Barrio, Becker, Becker, Berenstein, Claudson, de Wit, Douglas, Flume, Harvey, Hata, Hyun, Hyun, Kazama, Kazama, Kazama, Kazama, Kraus, Lowe, Maldacena, McArthur, Morales, Morales, Nicolai, Okawa, Okawa, Okawa, Paban, Paban, Plefka, Plefka, Sethi, Susskind, T. Muramatsu, Taylor, Y. Kazama   +37 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source