Results 41 to 50 of about 5,169 (253)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

W-infinity ward identities and correlation functions in the c=1 matrix model

, 1992
We explore consequences of W-infinity symmetry in the fermionic field theory of the c=1 matrix model. We derive exact Ward identities relating correlation functions of the bilocal operator.
Mandal, Gautam, Dhar, Avinash, Wadia, Spenta R., Das, Sumit R.   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Perturbed conformal field theory, nonlinear integral equations and spectral problems [PDF]

, 2000
This thesis is concerned with various aspects of perturbed conformal field theory and the methods used to calculate finite-size effects of integrable quantum field theories.
Dunning, Tania Clare, Tania Clare Dunning, Dunning, T.C.   +2 more
core  

On refined Chern-Simons and refined ABJ matrix models

, 2022
We consider the matrix model of U(N) refined Chern-Simons theory on S-3 for the unknot. We derive a q-difference operator whose insertion in the matrix integral reproduces an infinite set of Ward identities which we interpret as q-Virasoro constraints ...
Zabzine, Maxim,, Zabzine, Maxim, Cassia, Luca,, Cassia, Luca, Maxim Zabzine, Luca Cassia   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Matrix-Operator Formulation of Conformable Sylvester and Lyapunov Differential Matrix Equations

Journal of Mathematics
This paper presents a systematic matrix-operator formulation for linear Sylvester and Lyapunov matrix differential equations governed by the conformable derivative.
Ibtisam Aldawish, Wasim Raza, Lakhlifa Sadek, Ahmad Shafee   +3 more
doaj   +1 more source

Some Properties of Generalized Apostol-Type Frobenius–Euler–Fibonacci Polynomials

Mathematics
In this paper, by using the Golden Calculus, we introduce the generalized Apostol-type Frobenius–Euler–Fibonacci polynomials and numbers; additionally, we obtain various fundamental identities and properties associated with these polynomials and numbers,
Maryam Salem Alatawi, Waseem Ahmad Khan, Can Kızılateş, Cheon Seoung Ryoo   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source