Results 71 to 80 of about 6,085 (261)

A generalization of Tyler's M-estimators to the case of incomplete data [PDF]

Many different robust estimation approaches for the covariance or shape matrix of multivariate data have been established until today. Tyler's M-estimator has been recognized as the 'most robust' M-estimator for the shape matrix of elliptically symmetric
Jaekel, Uwe, Frahm, Gabriel
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Prototypes and matrix relevance learning in complex fourier space [PDF]

, 2017
In this contribution, we consider the classification of time-series and similar functional data which can be represented in complex Fourier coefficient space.
Melchert, F., T. Villmann, Biehl, M., M. Biehl, Kaden, M., Melchert, Friedrich, Biehl, M.; id_orcid, Villmann, Thomas, Straat, M., Gay, M., Straat, Michiel, Seiffert, Udo, F. Melchert, Biehl, Michael, Lampe, Alexander, M. Straat, Gay, Matthias, U. Seiffert, A. Lampe, M. Kaden, Kaden, Marika, Villmann, T., M. Gay, Seiffert, U.   +23 more
core   +1 more source

Mechanika Sprężonych i Zbrojonych Konstrukcji Prętowych w Ujęciu Reologicznym

Engineering Transactions, 1962
The results of Refs. [1] and [2] are used to obtain accurate effective closed and possibly general rheomechanical solutions for bar structures reinforced and prestressed in any manner, by means of methods of the matricial calculus and Laplace ...
Z. Wiśniewski
doaj  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Matrix monotone functions [PDF]

, 2018
This thesis is about Loewner's theory of matrix monotone functions. Matrix monotone functions of order n are real functions which, when lifted via functional calculus, preserve Loewner order on n x n Hermitian matrices.
Heinävaara, Otte
core  

The calculus of many instantons

, 2002
We describe the modern formalism, ideas and applications of the instanton calculus for gauge theories with, and without, supersymmetry. Particular emphasis is put on developing a formalism that can deal with any number of instantons.
Dorey, N., Mattis, M.P., Hollowood, T.J., Khoze, V.V., Timothy Hollowood   +4 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source