Results 51 to 60 of about 6,085 (261)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Multidual Complex Numbers and the Hyperholomorphicity of Multidual Complex-Valued Functions
AxiomsWe develop a rigorous algebraic–analytic framework for multidual complex numbers DCn within the setting of Clifford analysis and establish a comprehensive theory of hyperholomorphic multidual complex-valued functions.
Ji Eun Kim
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
On the use of functional calculus for phase-type and related distributions [PDF]
, 2014 The area of phase-type distributions is renowned for its ability to obtain closed form formulas or algorithmically exact solutions to many complex stochastic models.
Bladt, Mogens +2 more
core
Simplifying instanton corrections to N=4 SYM correlators [PDF]
, 2014 This article is distributed under the terms of the Creative Commons Attribution License (CC-BY 4.0), which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are ...
Bianchi, M +7 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
A matrix formulation of quantum stochastic calculus
, 1998 We develop the theory of chaos spaces and chaos matrices. A chaos space is a Hilbert space with a fixed, countably-infinite, direct-sum decomposition. A chaos matrix between two chaos spaces is a doubly-infinite matrix of bounded operators which respects
Belton, Alexander C. R. +1 more
core +1 more source
The Szász inequality for matrix polynomials and functional calculus
The Szász inequality is a classical result that provides a bound for polynomials with zeros in the upper half of the complex plane, expressed in terms of their low-order coefficients. Generalizations of this result to polynomials in several variables have been obtained by Borcea-Brändén and Knese.
Pikul, Piotr +2 more
openaire +2 more sources