Results 41 to 50 of about 6,085 (261)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
A fractal-fractional order Susceptible-Exposed-Infected-Recovered (SEIR) model with Caputo sense
Healthcare AnalyticsThis study explores the intricacies of the COVID-19 pandemic by employing a four-compartment model with a fractal-fractional derivative based on Caputo concept.
Subrata Paul +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Spontaneous quantization of the Yang–Mills gradient flow
Nuclear Physics BWe formulate a nonsingular loop–space calculus for the Yang–Mills (YM) gradient flow directly in terms of Wilson loop functionals, rather than the underlying gauge fields.
Alexander Migdal
doaj +1 more source
A functional calculus and the complex conjugate of a matrix
, 2017 Based on Stokes' theorem we derive a non-holomorphic functional calculus for matrices, assuming sufficient smoothness near eigenvalues, corresponding to the size of related Jordan blocks. It is then applied to the complex conjugation function $τ: z \mapsto \overline z$.
openaire +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Finite group gauge theory on graphs and gravity-like modes
Nuclear Physics BWe study gauge theory with finite group G on a graph X using noncommutative differential geometry and Hopf algebra methods with G-valued holonomies replaced by gauge fields valued in a ‘finite group Lie algebra’ subset of the group algebra CG ...
Shahn Majid, Francisco Simão
doaj +1 more source
Commutator Calculus and Symbolic Differentiation of Matrix Functions
SIAM Journal on Matrix Analysis and ApplicationsFor an application to the logarithmic corotational derivative, see https://doi.org/10.48550/arXiv.2504 ...
openaire +2 more sources