Results 91 to 100 of about 429,621 (305)

Problem of the gyroscopic stabilizer damping [PDF]

Applied and Computational Mechanics, 2009
The gyroscopic stabilization of the vibro-isolation system of an ambulance couch is analyzed. This paper follows several previous papers, which concern the derivation of the complete system of appropriate differential equations and some analyses were ...
Šklíba J.
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Fault detection and isolation of actuator failures for a large transport aircraft

, 2007
- We consider the problem of designing residual generators with least dynamical orders to solve actuator fault detection and isolation problems for a Boeing 747-100/200 aircraft. The main result of our analysis is the proof of feasibility of the complete
Varga, Andreas
core  

On computing minimal proper nullspace bases with applications in fault detection

, 2011
We discuss computationally efficient and numerically reliable algorithms to compute minimal proper nullspace bases of a rational or polynomial matrix.
Andras Varga, Varga, Andreas
core   +1 more source

Observer-based controller design for a vibration isolation stage having hybrid electromagnets

Journal of Low Frequency Noise, Vibration and Active Control, 2018
Vibration isolation systems based on hybrid electromagnets, consisting of electromagnet and permanent magnet, have a potential usage in many industrial areas, such as clean room design, transportation, semiconductor manufacturing, suspension systems, and
Barış Can Yalçın, Mert Sever, Kadir Erkan   +2 more
doaj   +1 more source

The Interplay and Synergism of Experiment and Quantum Chemistry in Research on Reactive Intermediates

CHIMIA, 2005
Three examples from the work of the author's research group on reactive intermediates are used to illustrate how fruitful interaction between experimental and computational chemistry may lead to the solution of problems that neither of the two ...
Thomas Bally
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Dynamic Modeling and Experimental Validation of Shock Isolation Performance for Shipborne Stewart-Platform-Based Bumper

Journal of Marine Science and Engineering
The Stewart-platform-based bumper plays a critical role in shipborne strap-down inertial navigation systems (SINSs), effectively mitigating shock-induced disturbances to ensure measurement accuracy.
Yongqiang Tu, Haoran Zhang, Yintao Li, Wei Wang, Gang Lu, Hongwei Lin, Xinkai Chen, Yan Huang, Jianyu Fan   +8 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Trehalose-enhanced isolation of neuronal sub-types from adult mouse brain

BioTechniques, 2012
Efficient isolation of specific, intact, living neurons from the adult brain is problematic due to the complex nature of the extracellular matrix consolidating the neuronal network.
Alka Saxena, Akiko Wagatsuma, Yukihiko Noro, Takenobu Kuji, Atsuko Asaka-Oba, Akira Watahiki, Cecile Gurnot, Michela Fagiolini, Takao K. Hensch, Piero Carninci   +9 more
doaj   +1 more source