Results 11 to 20 of about 2,335,867 (359)

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3 [PDF]

Cell, 1996
Peter C. Brooks, Staffan Strömblad, Luraynne C. Sanders, Tami L von Schalscha, Ronald T. Aimes, William G. Stetler‐Stevenson, James P. Quigley, David A. Cheresh   +7 more
openalex   +2 more sources

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

Proceedings of the National Academy of Sciences of the United States of America, 1990
Harold E. Van Wart, Henning Birkedal‐Hansen   +1 more
openalex   +2 more sources

The Role of Matrix Metalloproteinase in Inflammation with a Focus on Infectious Diseases

International Journal of Molecular Sciences, 2022
Matrix metalloproteinases (MMPs) are involved in extracellular matrix remodeling through the degradation of extracellular matrix components and are also involved in the inflammatory response by regulating the pro-inflammatory cytokines TNF-α and IL-1β ...
H. Lee, Woo Joo Kim
semanticscholar   +1 more source

Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell Differentiation

Frontiers in Physiology, 2021
Cells must alter their expression profiles and morphological characteristics but also reshape the extracellular matrix (ECM) to fulfill their functions throughout their lifespan.
Jiang-Tao Wan, Guowei Zhang, Xin Li, X. Qiu, Jun Ouyang, J. Dai, Shaoxiong Min   +6 more
semanticscholar   +1 more source

The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability

Mediators of Inflammation, 2020
Matrix metalloproteinase-9 (MMP-9) belongs to the MMP family and has been widely investigated. Excessive MMP-9 expression can enhance extracellular matrix degradation and promote plaque instability.
Tiewei Li, Xiaojuan Li, Yichuan Feng, Geng Dong, Yuewu Wang, Junmei Yang   +5 more
semanticscholar   +1 more source

Matrix Metalloproteinase

Definitions, 2020
Matrix metalloproteinases are Zn(2+)-binding endopeptidases that degrade components of the extracellular matrix. These enzymes are implicated in tissue remodeling processes, wound healing, angiogenesis, and tumor invasion.

semanticscholar   +1 more source

Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology

Pharmacological Reviews, 2022
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by its ability to degrade collagen. As their name suggests, matrix metalloproteinases are proteases capable of remodeling the extracellular matrix.
Luiz G. N. de Almeida, Hayley Thode, Yekta Eslambolchi, Sameeksha Chopra, D. Young, S. Gill, L. Devel, A. Dufour   +7 more
semanticscholar   +1 more source

Matrix metalloproteinases in cancer [PDF]

Essays in Biochemistry, 2002
The extracellular matrix (ECM) holds cells together and maintains the three-dimensional structure of the body. It also plays critical roles in cell growth, differentiation, survival and motility. For a tumour cell to metastasize from the primary tumour to other organs, it must locally degrade ECM components that are the physical barriers for cell ...
Itoh, Y, Nagase, H
openaire   +3 more sources

MMP-2 together with MMP-9 overexpression correlated with lymph node metastasis and poor prognosis in early gastric carcinoma

Tumor Biology, 2017
The aim of this study was to correlate matrix metalloproteinase-2 and matrix metalloproteinase-9 expression with the clinicopathological features and outcome of patients with early gastric cancer and to clinically elucidate more information on the role ...
Zhihua Yao, Tian Yuan, Haiying Wang, Shuna Yao, Yan Zhao, Ying Liu, Shuiling Jin, Junfeng Chu, Yuanlin Xu, Wenping Zhou, Shujun Yang, Yanyan Liu   +11 more
doaj   +1 more source

Protective Role of Matrix Metalloproteinase-2 in Allergic Bronchial Asthma

Frontiers in Immunology, 2019
Inflammation, reversible obstruction, and hyperresponsiveness of the airways are characteristic findings of bronchial asthma. Several evidence has demonstrated the involvement of matrix metalloproteinase-2 in allergic airway inflammation.
Yoshinori Takahashi, Tetsu Kobayashi, Corina N. D'Alessandro-Gabazza, Masaaki Toda, Kentaro Fujiwara, Tomohito Okano, Hajime Fujimoto, Kentaro Asayama, Atsuro Takeshita, Atsuro Takeshita, Taro Yasuma, Taro Yasuma, Kota Nishihama, Ryo Inoue, Liqiang Qin, Yoshiyuki Takei, Osamu Taguchi, Esteban C. Gabazza   +17 more
doaj   +1 more source