Results 281 to 290 of about 2,395,043 (357)

Role of matrix metalloproteinase‐3 in neurodegeneration

open access: yesJournal of Neurochemistry, 2011
Eun-mee Kim, O. Hwang
semanticscholar   +1 more source

Polycystin‐1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1‐Dependent Microfilament Remodeling

open access: yesAdvanced Science, EarlyView.
Polycystin‐1 (PC1) senses collagen and ECM stiffness to promote tumor migration via Daam1‐mediated actin remodeling. A cleavage‐resistant PC1 mutant enhances YAP nuclear translocation and CTGF expression, which activates CAFs and further stiffens the ECM, forming a feed‐forward loop that drives tumor progression and metastasis.
Jiaofeng Zhou   +12 more
wiley   +1 more source

Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms.

open access: bronze, 1998
John A. Curci   +4 more
openalex   +1 more source

T1WI‐SWI Dual Modal Magnetic Resonance Nanoprobes for Accurate Diagnosis of Early Stage Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
We developed a smart MRI nanoprobe targeting BACE1 and Aβ plaques. It crosses the blood‐brain barrier. Upon encountering BACE1, the probe is cleaved, enabling T1WI imaging detection. Subsequent reaction with ONOO− induces probe aggregation, enhancing magnetic susceptibility for sensitive SWI imaging of Aβ plaques.
Minghua Li   +13 more
wiley   +1 more source

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2000
Zhongjun Zhou   +8 more
semanticscholar   +1 more source

ACE‐mediated Glycosylation Stabilizes PSAP To Promote GPR37‐dependent Macrophage‐Nucleus Pulposus Cells Crosstalk and TGFβ Signaling in Alleviating Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
ACE can modulate the CBL‐mediated K48 ubiquitination degradation of PSAP by altering its glycosylation levels in NP cells. As a result, NP cells secrete PSAP, which interacts with GPR37 on macrophage surfaces, facilitating their polarization toward the M2 phenotype. These M2 macrophages subsequently secrete TGFβ, which exerts feedback effects on the NP
Youfeng Guo   +6 more
wiley   +1 more source

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