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Current Protocols in Cell Biology, 2008
AbstractMatrix metalloproteinases are a class of enzymes that play an important role in the remodeling of the extracellular matrix in development and cancer metastasis. This unit describes a set of methods—cell‐mediated dissolution of type‐1 collagen fibrils, direct and reverse zymography, enzyme capture based on α2‐macroglobulin and TIMP‐1 and ‐2, and
Henning, Birkedal-Hansen +6 more
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AbstractMatrix metalloproteinases are a class of enzymes that play an important role in the remodeling of the extracellular matrix in development and cancer metastasis. This unit describes a set of methods—cell‐mediated dissolution of type‐1 collagen fibrils, direct and reverse zymography, enzyme capture based on α2‐macroglobulin and TIMP‐1 and ‐2, and
Henning, Birkedal-Hansen +6 more
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Current Opinion in Chemical Biology, 1998
Matrix metalloproteinases are a family of highly regulated peptidases that are collectively responsible for the degradation of extracellular matrix during tissue remodeling. Dysregulated activity has long been implicated in the pathologies of cancer and arthritis, and the number of diseases more recently associated with these enzymes has been ...
L L, Johnson, R, Dyer, D J, Hupe
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Matrix metalloproteinases are a family of highly regulated peptidases that are collectively responsible for the degradation of extracellular matrix during tissue remodeling. Dysregulated activity has long been implicated in the pathologies of cancer and arthritis, and the number of diseases more recently associated with these enzymes has been ...
L L, Johnson, R, Dyer, D J, Hupe
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Matrix Metalloproteinases and Endometriosis [PDF]
Seminars in Reproductive Medicine, 2003 Retrograde menstruation represents a plausible explanation for the development of most cases of endometriosis; nevertheless, additional factors must contribute to the development of disease in only 10 to 20% of women. The discriminating factor(s) in determining the development of active endometriosis probably involves a complex array of potentially ...
Kaylon L. Bruner-Tran +2 more
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Matrix metalloproteinase inhibitors [PDF]
Breast Cancer Research and Treatment, 1997 Matrix metalloproteinases (MMPs) are a family of enzymes responsible for the breakdown of proteins of connective tissue. Through this action they play an important role in growth, development and tissue repair. Recent studies also suggest that MMPs are utilised in cancer, facilitating both local tumour invasion and metastasis.
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Current Protocols in Cell Biology, 2003
AbstractMatrix metalloproteinases are a class of enzymes that play an important role in the remodeling of the extracellular matrix in development and cancer metastasis. This unit describes a set of methods‐cell‐mediated dissolution of type I collagen fibrils, direct and reverse zymography, enzyme capture based on a‐2 macroglubulin and TIMP‐1 and ‐2 ...
William G. Stetler-Stevenson +6 more
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AbstractMatrix metalloproteinases are a class of enzymes that play an important role in the remodeling of the extracellular matrix in development and cancer metastasis. This unit describes a set of methods‐cell‐mediated dissolution of type I collagen fibrils, direct and reverse zymography, enzyme capture based on a‐2 macroglubulin and TIMP‐1 and ‐2 ...
William G. Stetler-Stevenson +6 more
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Matrix degrading metalloproteinases
Journal of Neuro-Oncology, 1994Matrix degrading metalloproteinases are enzymes that degrade proteins in tissue extracellular matrices. These proteinases exhibit specific, well defined properties that allow them to be classified into a family of enzymes. They are secreted by various cell types as the cells effect their surrounding extracellular matrix.
Bruce W. Ennis, Lynn M. Matrisian
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2012
Remodeling of extracellular matrix is crucial for many physiological (cell migration, proliferation, growth, and development) and pathological (remodeling of heart, carcinogenesis, metastasis, etc.) events. Thus, the interaction between cells and extracellular matrix plays a key role in normal development and differentiation of organism and many ...
Viola, Vargová +2 more
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Remodeling of extracellular matrix is crucial for many physiological (cell migration, proliferation, growth, and development) and pathological (remodeling of heart, carcinogenesis, metastasis, etc.) events. Thus, the interaction between cells and extracellular matrix plays a key role in normal development and differentiation of organism and many ...
Viola, Vargová +2 more
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Matrix metalloproteinases and atherosclerosis
Current Atherosclerosis Reports, 2004Atherosclerosis is a major cause of coronary heart disease, and matrix metalloproteinases (MMPs) play an important role in atherosclerosis by degrading the extracellular matrix, which results in cardiovascular remodeling. Recent studies have identified enhanced expression of MMPs in the atherosclerotic lesion and their contribution to weakening of the ...
Uichi Ikeda, Noboru Watanabe
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Matrix metalloproteinases and metastasis
Cancer Chemotherapy and Pharmacology, 1999Metastatic disease is responsible for the majority of cancer-related deaths, either directly due to tumor involvement of critical organs or indirectly due to complications of therapy to control tumor growth and spread. An understanding of the mechanisms of tumor cell invasion and metastasis may be important for devising therapies aimed at preventing ...
William G. Stetler-Stevenson +1 more
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