Results 331 to 340 of about 2,335,867 (359)

The Matrix Metalloproteinases and Their Inhibitors

American Journal of Respiratory Cell and Molecular Biology, 1992
A number of metalloproteinases that degrade the extracellular matrix of connective tissues and two specific tissue inhibitors of metalloproteinases (TIMPs) have now been isolated, characterized, and cloned. Comparison of the enzyme sequences has allowed the delineation of domain structures, and initial studies have been carried out to assess the ...
Andrew J. P. Docherty, Gillian Murphy
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Platelets and matrix metalloproteinases

Thrombosis and Haemostasis, 2013
SummaryMatrix metalloproteinases (MMPs) and their inhibitors essentially contribute to a variety of pathophysiologies by modulating cell migration, tissue degradation and inflammation. Platelet-associated MMP activity appears to play a major role in these processes.
Andreas E. May, Peter Seizer
openaire   +3 more sources

Sensitivity and specificity of a point-of-care matrix metalloproteinase 9 immunoassay for diagnosing inflammation related to dry eye.

JAMA ophthalmology, 2013
OBJECTIVES To determine the clinical sensitivity, specificity, negative predictive value, and positive predictive value of a rapid point-of-care diagnostic test to detect elevated matrix metalloproteinase 9 levels (InflammaDry).
R. Sambursky, W. Davitt, R. Latkany, S. Tauber, C. Starr, M. Friedberg, M. Dirks, M. McDonald   +7 more
semanticscholar   +1 more source

Matrix metalloproteinase processing of signaling molecules to regulate inflammation.

Periodontology, 2013
Inflammation is a complex and highly regulated process that facilitates the clearance of pathogens and mediates tissue repair. Failure to resolve inflammation can lead to chronic inflammatory diseases such as periodontitis.
Georgina S. Butler, C. Overall
semanticscholar   +1 more source

Matrix Metalloproteinases in Invertebrates

Protein & Peptide Letters, 2020
Matrix Metalloproteinases (MMPs) belong to a family of metal-dependent endopeptidases which contain a series of conserved pro-peptide domains and catalytic domains. MMPs have been widely found in plants, animals, and microorganisms. MMPs are involved in regulating numerous physiological processes, pathological processes, and immune responses.
Xi Liu, Dongwu Liu, Yangyang Shen, Mujie Huang, Lili Gao, Zonghan Zhang, Baohua Liu, Bosheng Zhao, Qiuxiang Pang   +8 more
openaire   +3 more sources

Matrix metalloproteinases in inflammation

Biochimica et Biophysica Acta (BBA) - General Subjects, 2014
Matrix metalloproteinases (MMPs) are a family of ubiquitously expressed zinc-dependent endopeptidases with broad substrate specificity and strictly regulated tissue specific expression. They are expressed in physiological situations and pathological conditions involving inflammation.
Liisa Nissinen, Veli-Matti Kähäri
openaire   +3 more sources

Matrix metalloproteinase inhibitors

Current Oncology Reports, 2004
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are associated with the tumorigenic process. MMPs degrade the extracellular matrix, promoting tumor invasion and metastasis. They also regulate host defense mechanisms and normal cell function; blocking all MMPs may not lead to a positive therapeutic outcome. Most clinical
Nithya Ramnath, Patrick J. Creaven
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Matrix Metalloproteinases and the Thyroid

Thyroid, 2000
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade components of the extracellular matrix (ECM) and basement membrane. They play a critical role in many physiological and pathological processes, such as tumor metastasis. The original concept-that MMP activity during metastasis is restricted solely to invasion of the basement membrane
Z. Kraiem, S. Korem
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Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer

Seminars in Oncology, 2002
Preclinical studies have provided evidence that matrix metalloproteinases (MMPs), a family of zinc-containing proteolytic enzymes, facilitate tumor invasion, the establishment of metastases, and the promotion of tumor-related angiogenesis. Matrix metalloproteinase inhibitors (MMPIs) have been shown to inhibit tumor growth and dissemination in ...
openaire   +2 more sources

Matrix Metalloproteinases in Atherothrombosis

Progress in Cardiovascular Diseases, 2010
The metalloproteinases (MMPs, matrixins) are zinc-containing endopeptidases involved in the metabolism of extracellular matrix as well as in the cleavage of other proteins. The MMP family currently consists of 28 enzymes with somewhat different activities.
Magnus Bäck, Magnus Bäck, Daniel F. J. Ketelhuth, Stefan Agewall   +3 more
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