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Matrix metalloproteinases and bone
Bone, 2008Matrix metalloproteinases (MMPs) are members of a family of zinc-dependent proteolytic enzymes. Several of the MMPs are expressed at high levels in bone and cartilage in mammals including humans and mice and are capable of cleaving native, undenatured collagens with long uninterrupted triple helices; these MMPs therefore potentially function as ...
Masaki Inada, Stephen M. Krane
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Matrix metalloproteinases in pneumonia
Clinica Chimica Acta, 2014Pneumonia is a worldwide infectious disease that is associated with significant morbidity and mortality and is the most common fatal infection acquired in hospitals. Despite advances in preventive strategies, such as antibiotic therapies and intensive care, the mortality rate still requires substantial improvement.
Shun-Fa Yang +3 more
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Matrix metalloproteinases and angiogenesis
Current Opinion in Nephrology and Hypertension, 2002Angiogenesis is a prominent feature of numerous diseases, including cancer and arthritis, and appears to play an important role in kidney disease and hypertension. The matrix metalloproteinases, especially matrix metalloproteinase-2, play a vital role during angiogenesis by degrading the surrounding extracellular matrix and allowing endothelial cell ...
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Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview.
European journal of medicinal chemistry, 2020S. Mondal +4 more
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Matrix Metalloproteinases and Their Inhibitors
2001Matrix metalloproteinases (MMPs) are a group of 16 enzymes that are capable of degrading extracellular matrix components. Their catalytic function is dependent on a zinc ion in the active center. MMPs are separated in three groups: gelatinases (type IV-collagenases), stromelysins, and interstitial collagenases.
Paul Thelen +2 more
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The matrix‐degrading metalloproteinases
BioEssays, 1992AbstractThe matrix‐degrading metalloproteinases are an intriguing family of enzymes that have evolved to digest specific extracellular matrix components. The expression of these enzymes is very highly regulated and can be controlled transcriptionally by a number of growth factors, tumor promoters, oncogenes, and hormones.
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Matrix metalloproteinases in repair
Wound Repair and Regeneration, 1999During repair, many different matrix metalloproteinases are produced by multiple cell types residing in various compartments within the wound environment. This diversity of enzymes, coupled with discreet cellular expression, implies that different matrix metalloproteinases serve different functions, acting on a variety of substrates, during wound ...
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A matrix metalloproteinase expressed on the surface of invasive tumour cells
Nature, 1994Hiroshi Sato +6 more
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Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
Science, 2002L. Coussens, B. Fingleton, L. Matrisian
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Matrix metalloproteinase functions in hepatic injury and fibrosis.
Matrix Biology, 2017M. Roderfeld
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