A muscle cell-macrophage axis involving matrix metalloproteinase 14 facilitates extracellular matrix remodeling with mechanical loading. [PDF]
FASEB J, 2022 Abstract The extracellular matrix (ECM) in skeletal muscle plays an integral role in tissue development, structural support, and force transmission. For successful adaptation to mechanical loading, remodeling processes must occur.
Peck BD +9 more
europepmc +4 more sources
Functional relationship between matrix metalloproteinase-11 and matrix metalloproteinase-14. [PDF]
Cancer Med, 2014 AbstractMMP‐11 is a key factor in physiopathological tissue remodeling. As an active form is secreted, its activity must be tightly regulated to avoid detrimental effects. Although TIMP‐1 and TIMP‐2 reversibly inhibit MMP‐11, another more drastic scenario, presumably via hydrolysis, could be hypothesized.
Buache E +10 more
europepmc +5 more sources
Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity. [PDF]
Mol Cell Biol, 2020 Fibrosis is recognized as the major pathological change in adipose tissue during the development of obesity. However, the detailed mechanisms governing the interactions between the fibrotic components and their modifiers remain largely unclear. Here, we reported that matrix metalloproteinase 14 (MMP14), a key pericellular collagenase, is dramatically ...
Li X +11 more
europepmc +4 more sources
Matrix metalloproteinase 14 modulates signal transduction and angiogenesis in the cornea. [PDF]
Surv Ophthalmol, 2016 The cornea is transparent and avascular, and retention of these characteristics is critical to maintaining vision clarity. Under normal conditions, wound healing in response to corneal injury occurs without the formation of new blood vessels; however, neovascularization may be induced during corneal wound healing when the balance between proangiogenic ...
Chang JH +7 more
europepmc +4 more sources
Cryptotanshinone inhibits lung cancer invasion via microRNA-133a/matrix metalloproteinase 14 regulation. [PDF]
Oncol Lett, 2019 Cryptotanshinone inhibits the proliferative and colony formation abilities of human non-small cell lung cancer cells (NSCLCs). The present study reported that signal transducer and activator of transcription 3 is not the only target of cryptotanshinone during the inhibition of human NSCLCs.
Wang H, Zhang Y, Zhang Y, Liu W, Wang J.
europepmc +4 more sources
Matrix metalloproteinase 14 overexpression reduces corneal scarring [PDF]
Gene Therapy, 2010 Abstract Purpose Corneal wound healing is an everyday preoccupation for ophthalmologists.Corneal transparency depends on the scarring quality after a traumatic corneal wound, but also after refractive corneal surgery. Cicatrisation and fibrosis formation involve epithelial/fibroblast interactions via paracrin signals inducing extracellular matrix (ECM)
S D, Galiacy +8 more
openaire +2 more sources
Lumican: A new inhibitor of matrix metalloproteinase‐14 activity [PDF]
FEBS Letters, 2014 We previously showed that lumican regulates MMP‐14 expression. The aim of this study was to compare the effect of lumican and decorin on MMP‐14 activity. In contrast to decorin, the glycosylated form of lumican was able to significantly decrease MMP‐14 activity in B16F1 melanoma cells.
Pietraszek, Katarzyna +7 more
openaire +3 more sources
Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration. [PDF]
J Biol Chem, 2011 Matrix metalloproteinases (MMPs) have been shown to be key players in both extracellular matrix remodeling and cell migration during cancer metastasis. MMP-14, a membrane-anchored MMP, in particular, is closely associated with these processes. The hemopexin (PEX) domain of MMP-14 has been proposed as the modulating region involved in the molecular ...
Zarrabi K +9 more
europepmc +4 more sources
Matrix metalloproteinase 14 regulates HSV-1 infection in neuroblastoma cells
Antiviral Research, 2021 Growing evidence supports that chronic or latent infection of the central nervous system might be implicated in Alzheimer's disease (AD). Among them, Herpes simplex virus type 1 (HSV-1) has emerged as a major factor in the etiology of the disease.
Patricia Llorente +5 more
openaire +4 more sources
C-reactive protein deficiency ameliorates experimental abdominal aortic aneurysms
Frontiers in Immunology, 2023 BackgroundC-reactive protein (CRP) levels are elevated in patients with abdominal aortic aneurysms (AAA). However, it has not been investigated whether CRP contributes to AAA pathogenesis.MethodsCRP deficient and wild type (WT) male mice were subjected ...
Yu Fu +19 more
doaj +1 more source