Results 221 to 230 of about 122,315 (249)
Some of the next articles are maybe not open access.
Matrix metalloproteinase-14 triggers an anti-inflammatory proteolytic cascade in endotoxemia
Journal of Molecular Medicine, 2017ᅟ: Matrix metalloproteinases can modulate the inflammatory response through processing of cyto- and chemokines. Among them, MMP-14 is a non-dispensable collagenase responsible for the activation of other enzymes, triggering a proteolytic cascade. To identify the role of MMP-14 during the pro-inflammatory response, wildtype and Mmp14 -/- mice were ...
Alina, Aguirre +9 more
openaire +2 more sources
Talanta, 2023
As transmembrane proteolytic enzyme, matrix metalloproteinase-14 (MMP14) regulates cell migration and cancer metastasis, but how it works at the single molecule level is unclear. Molecular localization is closely related to its function, and revealing its spatial assemble details is thus helpful to understand bio-function.
Dian, Ge +5 more
openaire +2 more sources
As transmembrane proteolytic enzyme, matrix metalloproteinase-14 (MMP14) regulates cell migration and cancer metastasis, but how it works at the single molecule level is unclear. Molecular localization is closely related to its function, and revealing its spatial assemble details is thus helpful to understand bio-function.
Dian, Ge +5 more
openaire +2 more sources
Materials Express, 2021
This study examined the basic regulatory effects and clinical value of metalloproteinase-14 and extracellular matrix metalloproteinase inducer in diabetic retinopathy. Seventy-four patients with diabetic retinopathy (study group/diabetic retinopathy (DR) group) and 48 healthy people (control group) were included in this study. Venous blood of subjects
Shuyan Li +7 more
openaire +1 more source
This study examined the basic regulatory effects and clinical value of metalloproteinase-14 and extracellular matrix metalloproteinase inducer in diabetic retinopathy. Seventy-four patients with diabetic retinopathy (study group/diabetic retinopathy (DR) group) and 48 healthy people (control group) were included in this study. Venous blood of subjects
Shuyan Li +7 more
openaire +1 more source
Analysis of apolipoprotein A-I as a substrate for matrix metalloproteinase-14
Biochemical and Biophysical Research Communications, 2011Substrates for matrix metalloproteinase (MMP)-14 were previously identified in human plasma using proteomic techniques. One putative MMP-14 substrate was apolipoprotein A-I (apoA-I), a major component of high-density lipoprotein (HDL). In vitro cleavage assays showed that lipid-free apoA-I is a more accessible substrate for MMP-14 compared to lipid ...
Jun Hyoung, Park +4 more
openaire +2 more sources
Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer
Digestive Diseases and Sciences, 2013Matrix metalloproteinase-14 (MMP-14) has been considered to play an important role in invasion and metastasis of human solid tumor.The present study aimed to investigate the association of MMP-14 with overall survival in human gastric cancer.Gastric cancer and adjacent normal specimens were collected from 205 patients who had not received neoadjuvant ...
Liang, He +7 more
openaire +2 more sources
A proteomic approach to identify substrates of matrix metalloproteinase-14 in human plasma
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2004Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that proteolyze extracellular matrix components as well as a variety of functional proteins. Here we describe a "degradomics" method that efficiently identifies substrates of MMP-14 in a complex protein mixture, such as plasma. Plasma proteins were incubated in the presence
In Kwan, Hwang +3 more
openaire +2 more sources
Matrix metalloproteinase 14 modulates diabetes and Alzheimer’s disease cross-talk: a meta-analysis
Neurological Sciences, 2017Diabetes mellitus is associated with dementia, but whether diabetes is associated with Alzheimer's disease remains controversial. Alzheimer's disease is characterized by amyloid beta aggregation. We hypothesized that genes, involved in amyloid beta degradation, may be altered due to diabetes and thus participate in progression of Alzheimer's disease ...
Jack Cheng +5 more
openaire +2 more sources
Journal of Endocrinological Investigation, 2003
Our study previously showed that estrogen and progesterone stimulated the production of matrix metalloproteinase-14 [MMP-14, or also named membrane type matrix metalloproteinses-1 (MT1-MMP)] in osteoblastic cells. MMP-14 was implied to regulate the function of osteoblasts by degrading bone matrix or growth factors, but the mechanism is unclear.
X H, Luo +5 more
openaire +2 more sources
Our study previously showed that estrogen and progesterone stimulated the production of matrix metalloproteinase-14 [MMP-14, or also named membrane type matrix metalloproteinses-1 (MT1-MMP)] in osteoblastic cells. MMP-14 was implied to regulate the function of osteoblasts by degrading bone matrix or growth factors, but the mechanism is unclear.
X H, Luo +5 more
openaire +2 more sources
[Gene expression of matrix metalloproteinase 14 in laryngeal squamous cell carcinoma].
Zhonghua er bi yan hou ke za zhi, 2013To investigate the role of expression of matrix metallo-proteinase 14 (MMP14) in laryngeal carcinomas and the relationship between MMP14 expression and the laryngeal biological behavior.The gene expression differences of MMP14 between fresh laryngeal cancer tissues and their surrounding normal mucosa was analyzed by RT-PCR.
Ye-hai, Liu +8 more
openaire +1 more source