Results 21 to 30 of about 122,315 (249)

Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target. [PDF]

PLoS ONE, 2009
BACKGROUND:The goal of our study was to molecularly dissect mesothelioma tumour pathways by mean of microarray technologies in order to identify new tumour biomarkers that could be used as early diagnostic markers and possibly as specific molecular ...
Stefania Crispi, Raffaele A Calogero, Mario Santini, Pasquale Mellone, Bruno Vincenzi, Gennaro Citro, Giovanni Vicidomini, Silvia Fasano, Rosaria Meccariello, Gilda Cobellis, Simona Menegozzo, Riccardo Pierantoni, Francesco Facciolo, Alfonso Baldi, Massimo Menegozzo   +14 more
doaj   +1 more source

MMP14 expression levels accurately predict the presence of extranodal extensions in oral squamous cell carcinoma: a retrospective cohort study

BMC Cancer, 2023
Background Extranodal extension (ENE) is an adverse prognostic factor for oral squamous cell carcinoma (OSCC), and patients with OSCC along with ENE require neck dissection.
Yuri Noda, Mitsuaki Ishida, Ryosuke Yamaka, Yasuhiro Ueno, Tomofumi Sakagami, Takuo Fujisawa, Hiroshi Iwai, Koji Tsuta   +7 more
doaj   +1 more source

Monoacylglycerol Lipase Knockdown Inhibits Cell Proliferation and Metastasis in Lung Adenocarcinoma

Frontiers in Oncology, 2020
Abnormal metabolism is one of the hallmarks of cancer cells. Monoacylglycerol lipase (MGLL), a key enzyme in lipid metabolism, has emerged as an important regulator of tumor progression.
Hao Zhang, Wei Guo, Fan Zhang, Renda Li, Yang Zhou, Fei Shao, Fei Shao, Xiaoli Feng, Fengwei Tan, Jie Wang, Shugeng Gao, Yibo Gao, Jie He   +12 more
doaj   +1 more source

Longitudinal Evaluation of Biomarkers in Wound Fluids from Venous Leg Ulcers and Split-thickness Skin Graft Donor Site Wounds Treated with a Protease-modulating Wound Dressing

Acta Dermato-Venereologica, 2022
Venous leg ulcers represent a clinical challenge and impair the quality of life of patients. This study examines impaired wound healing in venous leg ulcers at the molecular level.
Jacek Mikosiński, Konstantinos Kalogeropoulos, Louise Bundgaard, Cathrine Agnete Larsen, Simonas Savickas, Aleksander Moldt Haack, Konrad Pańczak, Katarzyna Rybołowicz, Tomasz Grzela, Michał Olszewski, Piotr Ciszewski, Karina Sitek-Ziółkowska, Krystyna Twardowska-Saucha, Marek Karczewski, Daniel Rabczenko, Agnieszka Segiet, Patrycja Buczak-Kula, Erwin M. Schoof, Sabine A. Eming, Hans Smola, Ulrich auf dem Keller   +20 more
doaj   +1 more source

Bone Marrow–Derived Matrix Metalloproteinase-14 [PDF]

Circulation, 2008
Our understanding of the role of bone marrow (BM)–derived cells in the pathogenesis of vascular disease has been evolving rapidly. It is generally accepted that circulating monocytes, the precursors of macrophages, migrate to the vascular wall and differentiate into lipid-laden macrophages in the process of atherogenesis.1 BM-derived cells with smooth ...
openaire   +1 more source

Δ⁸⁽¹⁴⁾-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase

Molecules, 2021
Arthritis is a chronic inflammatory disease accompanied by pathological reactions such as swelling, redness, fever, and pain in various joint areas. The drugs currently available to treat arthritis are associated with diverse side-effects.
Hyejin Moon, Myoungsil Ko, Yujin Park, Jeonguk Kim, Dowon Yoon, Eunjoohwang Lee, Taehoon Lee, Hakwon Kim   +7 more
doaj   +1 more source

Selective estrogen receptor modulators decrease invasiveness in pituitary adenoma cell lines AtT‐20 and TtT/GF by affecting expression of MMP‐14 and ADAM12

FEBS Open Bio, 2020
Selective estrogen receptor modulators (SERMs) significantly affect survival and invasiveness of rodent pituitary adenoma (PA) cells. The impact of three clinically relevant SERMs (bazedoxifene, clomiphene, raloxifene) on invasiveness and on gene and ...
Zhuo Zhang, Jörg W. Bartsch, Julia Benzel, Ting Lei, Christopher Nimsky, Benjamin Voellger   +5 more
doaj   +1 more source

Increased serum level of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP-14) in patients with breast cancer.

Folia Histochemica et Cytobiologica, 2010
Different types of matrix metalloproteinases, including membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) can be easily detected in biological fluids and therefore may be contemplated as putative tumor markers.
M Wojtukiewicz, M Leśniewska, L Kozłowski, J Swiatecka, P Laudański, S Wołczyński   +5 more
doaj   +1 more source

Matrix metalloproteinase MMP-8, TIMP-1 and MMP-8/TIMP-1 ratio in plasma in methicillin-sensitive Staphylococcus aureus bacteremia.

PLoS ONE, 2021
BackgroundMatrix metalloproteinase-8 (MMP-8) and tissue inhibitor of metalloproteinases-1 (TIMP-1) have been shown to predict prognosis in sepsis. However, MMP-8 and TIMP-1 in Staphylococcus aureus bacteremia (SAB) lacks evaluation and their role in the ...
Erik Forsblom, Taina Tervahartiala, Eeva Ruotsalainen, Asko Järvinen, Timo Sorsa   +4 more
doaj   +1 more source

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis [PDF]

Cancer Research, 2009
Abstract Inhibition of specific matrix metalloproteinases (MMP) is an attractive noncytotoxic approach to cancer therapy. MMP-14, a membrane-bound zinc endopeptidase, has been proposed to play a central role in tumor growth, invasion, and neovascularization.
Devy, L., Huang, L., Naa, L., Yanamandra, N., Pieters, H., Frans, N., Chang, E., Tao, Q., Vanhove, M., Lejeune, Annabelle, van Gool, R., Sexton, D. J., Kuang, G., Rank, D., Hogan, S., Pazmany, C., Ma, Y. L., Schoonbroodt, S., Nixon, A. E., Ladner, R. C., Hoet, R., Henderikx, P., TenHoor, C., Rabbani, S. A., Valentino, M. L., Wood, C. R., Dransfield, D. T.   +26 more
openaire   +3 more sources