Adipogenic Histone Mark Regulation by Matrix Metalloproteinase 14 in Collagen-Rich Microenvironments [PDF]
Molecular Endocrinology, 2011 Adipogenesis is directed by both transcriptional network and posttranslational modification of chromatin structure. Although adipogenesis in vivo proceeds in collagen-rich extracellular matrix (ECM) environments, the impact of ECM proteins and their modifying enzymes on the epigenetic regulation of adipogenesis has been largely unknown.
Kaori, Sato-Kusubata +3 more
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BMC Cancer, 2013 Background Recent evidence indicates that methyl jasmonate (MJ), a plant stress hormone, exhibits anti-cancer activity on human cancer cells. The aim of this study is to determine whether sub-cytotoxic MJ can abolish the migration, invasion and ...
Zheng Liduan +7 more
doaj +1 more source
LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis
Frontiers in Immunology, 2020 Liver fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) proteins and enzymes, especially fibrillary collagens, and represents a major cause of morbidity and mortality worldwide.
Mordehay Klepfish +9 more
doaj +1 more source
Characterising the intracellular trafficking of matrix Metalloproteinase 14 in macrophages [PDF]
, 2021 This thesis further elucidated the intracellular trafficking pathway of matrix metalloproteinase 14 (MMP14) in macrophages. It specifically investigated the trafficking pathway utilised by MMP14 for surface delivery in macrophages and the regulatory proteins that aid in this trafficking pathway.
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14-3-3 Protein is Detectable in Blood Serum and Fetlock Joint Synovial Fluid of High Performance Horses [PDF]
Iranian Journal of Veterinary Surgery, 2010 Objective: To investigate whether 14-3-3 eta protein is detectable in synovial fluid and blood serum of high performance horses and to study whether any significant correlation between this and matrix metalloproteinase 1 and 3 in horse synovial fluid ...
Kamran Sardari +4 more
doaj
The efficacy of conjunctiva coverage in combination with amnion liquid supernatant eye drop on deep layer corneal ulcer in canine caused by alkali burn combined with mechanical injury [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018 The purpose of this study was to establish the model of canine deep layer corneal ulcer by means of alkali burn combined with mechanical injury and evaluate the efficacy of conjunctival covering combined with amnion liquid supernatant deep layer corneal ...
Jiasan ZHENG +6 more
doaj +1 more source
Scientific Reports, 2021 To establish appropriate ex vivo models for a glaucomatous trabecular meshwork (TM), two-dimensional (2D) and three-dimensional (3D) cultures of human trabecular meshwork cells (HTM) were prepared in the presence of 250 nM dexamethasone (DEX) or 5 ng/mL ...
Megumi Watanabe +4 more
doaj +1 more source
miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14. [PDF]
Oncotarget, 2015 Recent evidence shows the emerging roles of endogenous microRNAs (miRNAs) in repressing gene transcription. However, the miRNAs inhibiting the transcription of matrix metalloproteinase 14 (MMP-14), a membrane-anchored MMP crucial for the tumorigenesis and aggressiveness, still remain largely unknown.
Xiang X +10 more
europepmc +4 more sources
Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms [PDF]
The Journal of Thoracic and Cardiovascular Surgery, 2012 It is hypothesized that an altered turnover of extracellular matrix mediated by matrix metalloproteinases (MMPs) is present in thoracic aortic aneurysms. Here, we analyzed the occurrence of MMPs and MMP inhibitors in ascending aortic aneurysms in patients with bicuspid and tricuspid aortic valves.Expression of 23 MMPs and their inhibitors was measured ...
Folkersen, Lasse +7 more
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Nanoparticle-mediated local delivery of an antisense TGF-β1 construct inhibits intimal hyperplasia in autogenous vein grafts in rats. [PDF]
PLoS ONE, 2012 Intimal hyperplasia is one of the most important causes of vascular graft failure. Numerous studies have correlated transforming growth factor-β1 (TGF-β1) with extracellular matrix (ECM) deposition, a hallmark of intimal thickening.In the present study ...
Da-Xin Sun +5 more
doaj +1 more source