Results 51 to 60 of about 122,315 (249)

Temporal Patterns of 14 Blood Biomarker candidates of Cardiac Remodeling in Relation to Prognosis of Patients With Chronic Heart Failure—The Bio‐SHiFT Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Remodeling biomarkers carry high potential for predicting adverse events in chronic heart failure (CHF) patients. However, temporal patterns during the course of CHF, and especially the trajectory before an adverse event, are unknown.
Elke Bouwens, Milos Brankovic, Henk Mouthaan, Sara Baart, Dimitris Rizopoulos, Nick van Boven, Kadir Caliskan, Olivier Manintveld, Tjeerd Germans, Jan van Ramshorst, Victor Umans, K. Martijn Akkerhuis, Isabella Kardys   +12 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

MMP14 as a central mediator of TGF-β1−induced extracellular matrix remodeling in graves’ orbitopathy

Frontiers in Endocrinology
BackgroundGraves’ orbitopathy (GO) is an autoimmune orbital disorder characterized by chronic inflammation and aberrant extracellular matrix (ECM) remodeling, leading to progressive fibrosis.
Xing Wang, Jing Lu, Yuxia He, Qinxin Shu, Yuxin Lin, Wenqi Su, Peng Wang   +6 more
doaj   +1 more source

High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1

Cancer Medicine, 2019
Matrix metalloproteinase 14 (MMP14), a membrane‐associated matrix metalloproteinase, has been shown to influence the invasion and metastasis of several solid tumors.
Aaro Kasurinen, Silvia Gramolelli, Jaana Hagström, Alli Laitinen, Arto Kokkola, Yuichiro Miki, Kaisa Lehti, Masakazu Yashiro, Päivi M. Ojala, Camilla Böckelman, Caj Haglund   +10 more
doaj   +1 more source

CM352 Reduces Brain Damage and Improves Functional Recovery in a Rat Model of Intracerebral Hemorrhage

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundIntracerebral hemorrhage (ICH) is an acute neurological disorder with high mortality and no effective treatment. In addition to the initial bleeding event, rebleeding and hematoma expansion are associated with poor outcome in these patients. We
José A. Rodríguez, Tomás Sobrino, Esteban López‐Arias, Ana Ugarte, Juan A. Sánchez‐Arias, Alba Vieites‐Prado, Irene de Miguel, Julen Oyarzabal, José A. Páramo, Francisco Campos, Josune Orbe, José Castillo   +11 more
doaj   +1 more source

Comparison of matrix metalloproteinase 9 and 14 levels in vitreous samples in diabetic and non-diabetic patients: a case control study

International Journal of Retina and Vitreous, 2022
Background MMP-9 plays a prominent role in inflammation and MMP-14 take part in angiogenesis. The objective of this study is to compare MMP-9 and MMP-14 levels between diabetic and non-diabetic patients.
A. Ünal, O. Baykal, N. Öztürk
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The Stiffness of Cardiac Fibroblast Substrates Exerts a Regulatory Influence on Collagen Metabolism via α2β1 Integrin, FAK and Src Kinases

Cells, 2021
Information about mechanical strain in the extracellular space is conducted along collagen fibers connected with integrins and then transmitted within cells.
Małgorzata Gałdyszyńska, Paulina Radwańska, Jacek Szymański, Jacek Drobnik   +3 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source