Results 161 to 170 of about 244,599 (206)
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Annals of the New York Academy of Sciences, 2006
Abstract: The pathogenesis of abdominal aortic aneurysm (AAAs) involves progressive cycles of proteolysis and inflammation, the product of proteolysis driving subsequent inflammation. Little is yet known about the initiating events. We review the specific literature examining the possibility that MMP‐2 may be the initial catalyst.
Matt, Thompson, Gillian, Cockerill
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Abstract: The pathogenesis of abdominal aortic aneurysm (AAAs) involves progressive cycles of proteolysis and inflammation, the product of proteolysis driving subsequent inflammation. Little is yet known about the initiating events. We review the specific literature examining the possibility that MMP‐2 may be the initial catalyst.
Matt, Thompson, Gillian, Cockerill
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Matrix Metalloproteinase-2 in Dentin Matrix Mineralization
Journal of Endodontics, 2001In the serum-free culture medium of bovine odontoblasts we detected active gelatinolytic metalloproteinases, matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases A and B). The activity of MMP-2, in particular, appeared suddenly around day 21 in the culture, coinciding with the development of odontoblastic cell processes and the loss of alkaline ...
M, Satoyoshi +6 more
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Clinical and Experimental Pharmacology and Physiology, 2010
Summary1. Matrix metalloproteinases (MMP) are associated with the vascular remodelling seen in atherosclerosis and aneurysm. The activation and activity of MMP‐2 are regulated by the intrinsic tissue inhibitor of MMP‐2 (TIMP‐2). The aim of the present study was to examine whether, conversely, MMP‐2 can affect the gene and protein expression of TIMP‐2.2.
Kaoru, Kimura +9 more
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Summary1. Matrix metalloproteinases (MMP) are associated with the vascular remodelling seen in atherosclerosis and aneurysm. The activation and activity of MMP‐2 are regulated by the intrinsic tissue inhibitor of MMP‐2 (TIMP‐2). The aim of the present study was to examine whether, conversely, MMP‐2 can affect the gene and protein expression of TIMP‐2.2.
Kaoru, Kimura +9 more
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Matrix Metalloproteinase 2: Involvement in Keratoconus
European Journal of Ophthalmology, 2000Purpose The activation of matrix metalloproteinase-2 (MMP-2) is postulated to be a crucial pathogenic factor behind progressive and chronic diseases in which basement membranes are disrupted. An ocular example is keratoconus. The purpose of the present enquiry was therefore to investigate and compare the activities of the MMP-2 secreted by keratocytes ...
V A, Smith, D L, Easty
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Matrix metalloproteinase-2 and matrix metalloproteinase-9 in mice with ocular toxocariasis
Parasitology Research, 2019In ocular toxocariasis, Toxocara canis-induced inflammatory reaction can lead to eye destruction and granuloma, which is formed by immune cell infiltration and concurrent extensive remodeling tissue. Herein, the histomorphology of granuloma and proteinase production in the eye of T. canis-infected BALB/c mice were investigated.
Ling-Yuh Shyu +2 more
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Matrix metalloproteinase-9 and matrix metalloproteinase-2 gene polymorphisms in multiple sclerosis
Journal of Neuroimmunology, 2008We investigated the association of matrix metalloproteinase-9 (-1562C/T, +279R/Q) and matrix metalloproteinase-2 (-1575G/A, -1306C/T) gene polymorphisms with multiple sclerosis (MS) susceptibility, gender differences and disability in 244 patients and 132 healthy subjects.
Yvonne, Benesová +7 more
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Matrix metalloproteinase-2 and Matrix metalloproteinase-9 in cholesteatoma and deep meatal skin
Clinical Otolaryngology and Allied Sciences, 1998A qualitative and quantitative study of the presence of Matrix metalloproteinase-2 (MMP-2) and Matrix metalloproteinase-9 (MMP-9) in cholesteatoma was performed. Ten cholesteatoma and four deep meatal skin specimens were analysed for gelatinase activity at molecular weights corresponding to MMP-2 and MMP-9 using Sodium Dodecyl Sulphate Polyacrylamide ...
A R, Banerjee, R, James, A A, Narula
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International Archives of Allergy and Immunology, 2006
<i>Background:</i> Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 can degrade type IV collagen which is the major component of the basement membrane zone (BMZ). In bullous pemphigoid (BP), the separation occurs within the BMZ. <i>Objective:</i> To evaluate the involvement of MMPs in the pathogenesis of BP, we examined the ...
Yayoi, Niimi +2 more
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<i>Background:</i> Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 can degrade type IV collagen which is the major component of the basement membrane zone (BMZ). In bullous pemphigoid (BP), the separation occurs within the BMZ. <i>Objective:</i> To evaluate the involvement of MMPs in the pathogenesis of BP, we examined the ...
Yayoi, Niimi +2 more
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2023
Endometriosis is a benign gynecological disease characterized by the presence of endometrial tissue; endometrial glands and stroma outside the uterus. Even though endometriosis affects about 0.7-8.6% women of the reproductive age, the pathogenesis is not well understood and there is no reliable non-invasive biomarker for diagnosis.
Maoga, Jane Bosibori +1 more
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Endometriosis is a benign gynecological disease characterized by the presence of endometrial tissue; endometrial glands and stroma outside the uterus. Even though endometriosis affects about 0.7-8.6% women of the reproductive age, the pathogenesis is not well understood and there is no reliable non-invasive biomarker for diagnosis.
Maoga, Jane Bosibori +1 more
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