Results 191 to 200 of about 700,477 (342)

Matrix metalloproteinase 2 destabilizes Dally-like protein to restrict extracellular Wingless distribution. [PDF]

Mol Biol Cell
Waghmare I, Page-McCaw PS, Page-McCaw A.
europepmc   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Matrix metalloproteinase-2 as a novel regulator of glucose utilization by adipocytes. [PDF]

Sci Rep
Lempicki MD, Garrigues RJ, Hondros AD, Zeczycki TN, Garcia BL, Cavanagh J, Harris TE, Meher AK.   +7 more
europepmc   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source

Bioresponsive Hyaluronic Acid-Based Hydrogel Inhibits Matrix Metalloproteinase-2 in Glioblastoma Microenvironment. [PDF]

ChemMedChem
Barbugian F, Salerno D, Ballarini E, Crippa L, Francesconi O, Mantegazza F, Cavaletti G, Roelens S, Leone G, Pepi S, Talarico L, Magnani A, Nativi C, Russo L.   +13 more
europepmc   +1 more source

Role of Matrix Metalloproteinase-2 in the Development of Atherosclerosis among Patients with Coronary Artery Disease. [PDF]

Mediators Inflamm, 2023
Samah N, Ugusman A, Hamid AA, Sulaiman N, Aminuddin A.   +4 more
europepmc   +1 more source

Myocardial matrix metalloproteinase-2: inside out and upside down.

Journal of Molecular and Cellular Cardiology, 2014
Ashley DeCoux, M. Lindsey, F. Villarreal, Ricardo A. García, R. Schulz   +4 more
semanticscholar   +1 more source

Immunomodulatory Hydrogel Coating with SeNPs and Lithium Silicate Synergistically Promotes Osseointegration and Prevents Infection on Titanium Implants

Advanced Science, EarlyView.
This study introduces a multifunctional hydrogel coating (Lap‐CMCSMA/GelMA@SeNPs) that scavenges ROS, modulates immune responses, and shows strong antibacterial activity. It effectively restores the peri‐implant microenvironment. The coating exhibits excellent biocompatibility and promotes osteogenic differentiation.
Su Jiang, Baisheng Cai, Cong Ye, Kefan Wu, Kuan Liu, Pengcheng Xu, Fan Liu, Yake Liu   +7 more
wiley   +1 more source

Association of Matrix Metalloproteinase-2 Promoter Genotypes With Leiomyoma Risk. [PDF]

Cancer Genomics Proteomics
Chang SY, Chang WS, Tsai CW, Wang YC, Shih HY, Su CH, Bau DT.   +6 more
europepmc   +1 more source

Involvement of PAR-2 in the Induction of Cell-Specific Matrix Metalloproteinase-2 by Activated Protein C in Cutaneous Wound Healing. [PDF]

Int J Mol Sci, 2023
Julovi SM, McKelvey K, Minhas N, Chan YA, Xue M, Jackson CJ.   +5 more
europepmc   +1 more source