Results 341 to 350 of about 331,204 (356)
Some of the next articles are maybe not open access.
Matrix Metalloproteinases in Invertebrates
Protein & Peptide Letters, 2020Matrix Metalloproteinases (MMPs) belong to a family of metal-dependent endopeptidases which contain a series of conserved pro-peptide domains and catalytic domains. MMPs have been widely found in plants, animals, and microorganisms. MMPs are involved in regulating numerous physiological processes, pathological processes, and immune responses.
Xi Liu +8 more
openaire +3 more sources
Matrix metalloproteinases in inflammation
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014Matrix metalloproteinases (MMPs) are a family of ubiquitously expressed zinc-dependent endopeptidases with broad substrate specificity and strictly regulated tissue specific expression. They are expressed in physiological situations and pathological conditions involving inflammation.
Liisa Nissinen, Veli-Matti Kähäri
openaire +3 more sources
Matrix metalloproteinase inhibitors
Current Oncology Reports, 2004Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are associated with the tumorigenic process. MMPs degrade the extracellular matrix, promoting tumor invasion and metastasis. They also regulate host defense mechanisms and normal cell function; blocking all MMPs may not lead to a positive therapeutic outcome. Most clinical
Nithya Ramnath, Patrick J. Creaven
openaire +3 more sources
Matrix Metalloproteinases and the Thyroid
Thyroid, 2000Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade components of the extracellular matrix (ECM) and basement membrane. They play a critical role in many physiological and pathological processes, such as tumor metastasis. The original concept-that MMP activity during metastasis is restricted solely to invasion of the basement membrane
Z. Kraiem, S. Korem
openaire +3 more sources
Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer
Seminars in Oncology, 2002Preclinical studies have provided evidence that matrix metalloproteinases (MMPs), a family of zinc-containing proteolytic enzymes, facilitate tumor invasion, the establishment of metastases, and the promotion of tumor-related angiogenesis. Matrix metalloproteinase inhibitors (MMPIs) have been shown to inhibit tumor growth and dissemination in ...
openaire +2 more sources
Matrix Metalloproteinases in Atherothrombosis
Progress in Cardiovascular Diseases, 2010The metalloproteinases (MMPs, matrixins) are zinc-containing endopeptidases involved in the metabolism of extracellular matrix as well as in the cleavage of other proteins. The MMP family currently consists of 28 enzymes with somewhat different activities.
Magnus Bäck +3 more
openaire +3 more sources
Matrix metalloproteinases and bone
Bone, 2008Matrix metalloproteinases (MMPs) are members of a family of zinc-dependent proteolytic enzymes. Several of the MMPs are expressed at high levels in bone and cartilage in mammals including humans and mice and are capable of cleaving native, undenatured collagens with long uninterrupted triple helices; these MMPs therefore potentially function as ...
Masaki Inada, Stephen M. Krane
openaire +3 more sources
Matrix metalloproteinases in pneumonia
Clinica Chimica Acta, 2014Pneumonia is a worldwide infectious disease that is associated with significant morbidity and mortality and is the most common fatal infection acquired in hospitals. Despite advances in preventive strategies, such as antibiotic therapies and intensive care, the mortality rate still requires substantial improvement.
Shun-Fa Yang +3 more
openaire +3 more sources
Matrix metalloproteinases and angiogenesis
Current Opinion in Nephrology and Hypertension, 2002Angiogenesis is a prominent feature of numerous diseases, including cancer and arthritis, and appears to play an important role in kidney disease and hypertension. The matrix metalloproteinases, especially matrix metalloproteinase-2, play a vital role during angiogenesis by degrading the surrounding extracellular matrix and allowing endothelial cell ...
openaire +3 more sources
Matrix Metalloproteinases and Their Inhibitors
2001Matrix metalloproteinases (MMPs) are a group of 16 enzymes that are capable of degrading extracellular matrix components. Their catalytic function is dependent on a zinc ion in the active center. MMPs are separated in three groups: gelatinases (type IV-collagenases), stromelysins, and interstitial collagenases.
Paul Thelen +2 more
openaire +3 more sources