Results 51 to 60 of about 1,507,141 (306)

Development of decision support system based on feature matrix for cyber threat assessment [PDF]

open access: yesInternational Journal of Electronics and Telecommunications, 2019
The article herein presents the method and algorithms for forming the feature space for the base of intellectualized system knowledge for the support system in the cyber threats and anomalies tasks.
Timur Kartbayev   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Fault Diagnosis Method for Railway Turnout with Pinball Loss-Based Multiclass Support Matrix Machine

open access: yesApplied Sciences, 2023
The intelligent maintenance of railway equipment plays a pivotal role in advancing the sustainability of transportation and manufacturing. Railway turnouts, being an essential component of railway infrastructure, often encounter various faults, which ...
Mingyi Geng, Zhongwei Xu, Meng Mei
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Cell–Biomaterial Interactions

open access: yesBioengineering, 2023
In animals, the extracellular matrix (ECM) forms a three-dimensional network occupying the intercellular spaces (interstitial matrix) or serving as physical and biochemical support for cells and tissues (basement membrane) [...]
Vincent Deplaigne, Gael Y. Rochefort
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Stress-induced toxic genomic R-loops support biofilm extracellular matrix formation

open access: yesNature Communications
Self-aggregation into biofilms is a bacterial stress response that promotes antimicrobial resistance because biofilms comprise viscous extracellular polymeric matrices that impede antimicrobial diffusion. Extracellular DNA (eDNA) is typically a principal
Sudarsan Mugunthan   +4 more
doaj   +1 more source

Matrix support work: difficulties in the scope of basic healthcare

open access: yesRevista Gaúcha de Enfermagem
Qualitative research under the analysis of contents, thematic modality, aimed to identify the difficulties lived by the matricial supporter in its practice in the Primary Health Care.
Amanda de Araújo ROMERA   +5 more
doaj   +1 more source

Research on laser positioning matrix of straightness detection robot for hydraulic support

open access: yesGong-kuang zidonghua, 2019
For straightness detection of hydraulic support in unmanned working face of coal mine underground, an attitude and straightness detection model of hydraulic support was proposed.
YANG Xuejun, WANG Ranfeng, WANG Huaifa
doaj   +1 more source

Entropy-Based Support Matrix Machine [PDF]

open access: yes, 2017
Support Vector Machine (SVM) cannot process imbalanced problem and matrix patterns. Thus, Fuzzy SVM (FSVM) is proposed to process imbalanced problem while Support Matrix Machine (SMM) is proposed to process matrix patterns. FSVM applies a fuzzy membership to each training pattern such that different patterns can make different contributions to the ...
openaire   +2 more sources

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