Results 91 to 100 of about 3,705,438 (306)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Linear multidimensional-matrix procrustes transformation

, 2010
The problem of linear multidimensional-matrix Procrustes transformation is formulated and solved An example of Procrustes transformation in case of two-dimensional matrices is ...
Mukha, V. S.
core  

Z-folding aircraft electromagnetic scattering analysis based on hybrid grid matrix transformation. [PDF]

Sci Rep, 2022
Zhou Z, Huang J.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Beamspace Transformation Matrix Design using Numerical Optimization

, 1992
This paper addresses the problem of designing a data-dimension reducing transformation matrix, to be used for beamspace direction-of-arrival (DOA) estimation. The design of the transformation matrix is based on numerical optimization techniques.
Andersson, Sören
core   +2 more sources

K-Means clustering outsourcing scheme based on sparse matrix transformation and bounded random perturbation

Tongxin xuebao
To address the problem that existing secure outsourcing schemes for K-Means clustering incur high computational and communication overhead, making them difficult to satisfy the efficiency requirements of practical applications, a privacy-preserving K ...
Zhao Wei, Tan Jingwen, Wang Huanran, Han Shuai, Yang Wu, Lai Mingzhu   +5 more
doaj  

Privacy Protection by Matrix Transformation

IEICE Transactions on Information and Systems, 2009
Privacy preserving is indispensable in data mining. In this paper, we present a novel clustering method for distributed multi-party data sets using orthogonal transformation and data randomization techniques. Our method can not only protect privacy in face of collusion, but also achieve a higher level of accuracy compared to the existing methods.
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Engineering d-orbital of copper single-atom sites toward industrial-level electrocatalytic methanation

Nature Communications
Copper (Cu)-based single-atom catalysts (SACs) enable electrocatalytic CO2 reduction into methane (CH4) fuel for thermal power plant decarbonization, yet conventional Cu SACs face industrial deployment barriers like instability and sluggish kinetics ...
Zhengzheng Liu, Junzhuo Cai, Shuming Dong, Chaoxiu Qin, Zhuoran Lv, Yu Yang, Jiacheng Jayden Wang, Jiaxu Gong, Huibin Zhang, Huazhen Cao, Anxiang Guan, Zhangliu Tian, Qing Han, Fengwang Li, Fuqiang Huang, Ximeng Lv, Guoqu Zheng   +16 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source