Results 121 to 130 of about 3,705,438 (306)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Integrable properties and soliton dynamics for the generalized n-component Sasa-Satsuma equation via the Dbar-dressing method

Nuclear Physics B
Based on a (2n+1)×(2n+1) matrix Dbar equation and two linear equations concerning the spectral transformation matrix, the generalized n-component Sasa-Satsuma (GNSS) equation is investigated via the Dbar-dressing method.
Qi Chen, Tao Deng, Chunxia Li, Yuqin Yao
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

SINGULAR RANDOM MATRIX DECOMPOSITIONS: DISTRIBUTIONS. [PDF]

Assuming that Y has a singular matrix variate elliptically contoured distribution with respect to the Hausdorff measure, the distributions of several matrices associated to QR, modified QR, SV and Polar decompositions of matrix Y are determined, for ...
Graciela González-Farías, José A. Díaz-García   +1 more
core  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A Convenient Mesh rotation method of finite element analysis using sub-matrix transformation approach

, 2012
This paper presents a novel sub-matrix transformation method on mesh rotation problems in the finite element analysis (FEA) of electric machines. This proposed approach is simple, convenient and readily implementable.
Niu, S, Fu, WN, Ho, SL, Zhu, J
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Modal Transformation Obtained From Clarke's Matrix - Asymmetrical Three-phase Case

, 2007
Some constant matrices can be used as phase-mode transformation matrices for transposed three-phase transmission lines. Clarke's matrix is one of these options.
Kurokawa, S., Bovolato, L. F., S. Kurokawa, Prado, A. J., L. F. Bovolato, Filho, J. Pissolato, A. J. Prado, J. Pissolato Filho, Bovolato L.F., Kurokawa S., Prado A.J., Filho J.P.   +11 more
core   +1 more source

Mass and Stiffness Correlation Using a Transformation Matrix

Infrastructures
Model correlation techniques are methods used to compare two different models, usually a numerical model and an experimental model. According to the structural dynamic modification theory, the experimental mode shapes estimated by modal analysis can be ...
Natalia García Fernández, Pelayo Fernández Fernandez, Rune Brincker, Manuel Aenlle López   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source