Results 51 to 60 of about 383,433 (233)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Dual JL Transforms and Superfast Matrix Algorithms

, 2021
We call a matrix algorithm superfast (aka running at sublinear cost) if it involves much fewer flops and memory cells than the matrix has entries. Using such algorithms is highly desired or even imperative in computations for Big Data, which involve ...
Luan, Qi, Pan, Victor Y., Svadlenka, John   +2 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Matrix generalizations of some dynamic field theories

, 1995
We introduce matrix generalizations of the Navier--Stokes (NS) equation for fluid flow, and the Kardar--Parisi--Zhang (KPZ) equation for interface growth.
A. Zee, Ala-Nissila, Barabasi, Barma, Bouchaud, Bouchaud, Brézin, Brézin, Brézin, DeDominicis, Deker, Doherty, Forster, Frey, Halpin-Healy, Hooft, Kardar, Kardar, Kardar, Kolmogorov, Kolmogorov, Krug, Lassig, Medina, Mehran Kardar, Mehta, Moore, Mou, Mou, Porter, Schwartz, Sun, Tu, Voiculescu, Yakhot, Zinn-Justin   +35 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Wavemoth -- Fast spherical harmonic transforms by butterfly matrix compression

, 2012
We present Wavemoth, an experimental open source code for computing scalar spherical harmonic transforms (SHTs). Such transforms are ubiquitous in astronomical data analysis.
D. S. Seljebotn, Eriksen, Górski, Hupca, Press, Suda, Szydlarski, Wiaux   +7 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Effects of Heat-Treatment on the Microstructure and Wear Resistance of a High-Chromium Cast Iron for Rolls

Advances in Materials Science and Engineering, 2016
The variations of microstructure and mechanical properties of a high-chromium cast iron for rolls were studied from as-cast to the final heat treatments.
Zhi-hong Guo, Fu-ren Xiao, Su-ling Lu, Han-yun Li, Bo Liao   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Efficient computation for the eigenvalues and eigenfunctions of two-dimensional non-separable linear canonical transform

Results in Applied Mathematics
The parameter matrix of the two-dimensional non-separable linear canonical transform (2D-NSLCT) determines its specific form and properties. Certain forms of the 2D-NSLCT are consistent with well-known transforms, such as two-dimensional non-separable ...
Yuru Tian, Feng Zhang
doaj   +1 more source