Results 81 to 90 of about 9,069,057 (289)

Imagining the Unimaginable: Narratives of the Big Bang: Time, Space, Matter, Energy

open access: yesJournal of Big History, 2018
The term big bang has an uneasy history of problematic and misleading implications. As a derogatory and simplistic metaphor it is incompatible with current understandings of Planck time, inflationary theory, self-organizing dynamics, and emergent ...
Barry Wood
doaj   +1 more source

Neutron stars with spin polarized self-interacting dark matter

open access: yes, 2018
Dark matter, one of the important portion of the universe, could affect the visible matter in neutron stars. An important physical feature of dark matter is due to the spin of dark matter particles.
Rezaei, Zeinab
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Materia i przyczynowość - konkrety czy uniwersalia?

open access: yesZagadnienia Filozoficzne w Nauce, 2011
Humean doctrine on causality is well known. Since all our knowledge comes from experience, we are able to know that “B follows A” (B propter A) but not that “B is caused by A” (B propter A). All the rest comes from our mental habits.
Michał Heller
doaj  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

BACK MATTER

open access: yesJINOP (Jurnal Inovasi Pembelajaran), 2018
BACK MATTER BACK MATTER
doaj   +3 more sources

On the concepts of time, space, vacuum and domain of investigation among contemporary physics, philosophy and theological reflection [PDF]

open access: yesPizhūhish/hā-yi Falsafī- Kalāmī
Contemporary theology is realizing the importance of integrating the knowledge ofmodern/contemporary physics into the metaphysical and ontological categories usedto consider God and the God-world relationship.
Paolo Di Sia
doaj   +1 more source

Weak Gravitational Lensing as a Method to Constrain Unstable Dark Matter

open access: yes, 2010
The nature of the dark matter remains a mystery. The possibility of an unstable dark matter particle decaying to invisible daughter particles has been explored many times in the past few decades.
Wang, Mei-Yu, Zentner, Andrew R.
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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