Results 171 to 180 of about 986,720 (307)

Right ventricular pressure overload disturbs T-tubule maturation via MEF2D's transcriptional regulation of BIN1. [PDF]

JCI Insight
Hu Y, Xue Y, Chen X, Kong L, Li D, Wang Z, Zheng S, She S, Li H, Sun S, Chen H, Chen L, Ruan P, Wang K, Ye L.   +14 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multidimensional maturation of oxytocin neurons: A principal component analysis of postnatal development. [PDF]

J Neuroendocrinol
Maejima Y, Suzuki M, Matsuoka W, Ueta Y, Shimomura K.   +4 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Correction: Mixed-maturation fisheries compromise productivity and resilience of Chinook salmon. [PDF]

Sci Rep
Gayeski N, Swanson D, MacDuffee M, Rosenberger A.   +3 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

From immature to mature epithelium: unveiling structural dynamics and transcriptional programs in rainbow trout intestinal barrier. [PDF]

Vet Res
Talamilla-Espinoza A, Vera-Tamargo F, Caruffo M, Hidalgo M, Ortiz D, Rodríguez L, Mandakovic D, Riveros A, Porras O, Pulgar R.   +9 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Effect of LH-RH Cholesterol Pellet on Ovarian Maturation in Ayu, Plecoglossus altivelis

, 1988
LH-RH cholesterol pellet formulated for a long delivery was administered to female Ayu, Plecoglossus altivelis which were maintained at ovarian maturation-suppressive condition of the long photoperiod (15L: 9D).
ヒロセ, ケイジ, Arai, Shiteru, 4195, Hirose, Keiji, 4174, 新井, 茂, 廣瀬, 慶二, アライ, シゲル   +7 more
core  

Sequential miRNA-mRNA profiling of regulatory pathways during in vitro maturation of canine oocytes. [PDF]

Anim Reprod
De Los Reyes M, Dettleff P, Palomino J, Peralta OA, Parraguez VH, Orellana B, Avendaño JM.   +6 more
europepmc   +1 more source