Results 181 to 190 of about 895,186 (317)

Skeletal Age Evaluation with BAUSport^TM Ultrasound in Young Slovak Female Athletes and Non-Athletes-A Cross-Sectional Study. [PDF]

J Funct Morphol Kinesiol
Švábová Nee Uhrová P, Cihová I, Soták M, Falbová D, Vorobeľová L, Beňuš R, Bundová L.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation

, 2018
Junsheng Fan,1,2,* Tszhei Fong,1,* Xinjie Chen,3,* Chuyun Chen,1 Peng Luo,1 Haiting Xie1 1Zhujiang Hospital of Southern Medical University, Guangzhou, China; 2Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China; 3Second School of ...
Luo P, Fong T, Fan J, Xie H, Chen X, Chen C   +5 more
core  

Extracellular vesicle-mediated signalling in human rescue <i>in vitro</i> maturation: methodological and mechanistic considerations. [PDF]

Hum Reprod Open
Sun X.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering the miRNA-TF-mRNA Regulatory Network Underlying Oocyte Maturation in Orange-Spotted Grouper (<i>Epinephelus coioides</i>): Insights from Oocyte mRNA-Seq and miRNA-Seq. [PDF]

Animals (Basel)
Zhang M, Wang Y, Liang D, Diao D, Li M, Tang Y, Miao Y, Yang Y, Liu S, Wu J, Zhang Y, Li S.   +11 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Sericin Supplementation Prior to and During In Vitro Maturation Mitigates H₂O₂-Induced Oxidative Stress in Bovine Oocytes. [PDF]

Vet Med Int
Yindeetrakul S, Triwutanon S, Sangmalee A, Rukkwamsuk T.   +3 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Medial cephalic to proximal ulnar artery fistulas enabled by a nitinol extravascular support device produce significantly higher maturation rates than brachial-based fistulas. [PDF]

J Vasc Surg Cases Innov Tech
Blessios G.
europepmc   +1 more source