Results 231 to 240 of about 986,720 (307)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The use of ex-vivo in-vitro maturation of ovarian tissues oocytes (OTO-IVM) for fertility preservation in gynaecologic cancers. [PDF]

Gynecol Oncol Rep
Goh CSY, Lim CJW, Ng QJ, Lee SH, Chin FHX, Lim YH, Phoon JWL, Sim YJ, Lee JM, Durgahshree M, Hou MCL, Chong YS, Ee TX.   +12 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Supplementation of lupeol during in vitro maturation improves preimplantation embryonic development in pigs. [PDF]

Vet Anim Sci
Lin Q, Otoi T, Widodo OS, Tharasanit T, Chatdarong K, Sambuu R, Nagahara M, Hirata M, Tanihara F, Namula Z.   +9 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Intrafollicular immature oocyte transfer (IFIOT): technical advances, biological insights and applications in reproductive biotechnologies. [PDF]

Anim Reprod
Sprícigo JFW, Chaves JEV, Dode MAN.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Global analysis of infant gut microbiota revealed distinctive maturation dynamics across lifestyles. [PDF]

NPJ Biofilms Microbiomes
Bücking R, Pasquali G, Löber U, Buss C, Viemann D, Jarquín-Díaz VH, Forslund-Startceva SK.   +6 more
europepmc   +1 more source