Results 241 to 250 of about 986,720 (307)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

CD86-Positive Mature Tertiary Lymphoid Structures Are Associated With CD8⁺ T-Cell Infiltration and Favorable Clinical Outcomes in Pancreatic Ductal Adenocarcinoma. [PDF]

Ann Gastroenterol Surg
Seki T, Araki K, Yokobori T, Ikota H, Kubo N, Igarashi T, Tsukagoshi M, Ishii N, Hosouchi Y, Saeki H, Shirabe K.   +10 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Rbp-Jκ controls NK cell late maturation and migration via chromatin landscape remodeling. [PDF]

Proc Natl Acad Sci U S A
Peng H, Yang Y, Liu Y, Wu S, Hu D, Deng X, Huang L, Li Y, Xiong P, Yang Q, Li S, Gong B, Zhang Y, Song L, Wang F, Yu J, Xiao Z, Deng Y, Zhong Z, Deng Y.   +19 more
europepmc   +1 more source

The Murine Epithelial Thymic Microenvironment Is Governed by Eph/Ephrin Signalling. [PDF]

Cells
Montero-Herradón S, Alfaro D, Zapata AG, García-Ceca J.   +3 more
europepmc   +1 more source

Serial Magnetic Resonance Imaging Graft Signal Intensity and its Correlation with Functional Recovery Following Primary Anterior Cruciate Ligament Reconstruction. [PDF]

J Orthop Case Rep
Malik S, Vasaikar PS, Senthilnathan PG, Gupta A, Singh M, Gupta S.   +5 more
europepmc   +1 more source

<i>Ex vivo</i> maturation of the malaria parasite egress protease SERA6 aids pathway dissection and inhibitor development. [PDF]

Front Parasitol
Withers-Martinez C, Taha Z, Collins CR, Hackett F, Tan MSY, Soudy C, Joshi D, Redmond J, Davies B, Maslen S, Skehel M, George R, Kjaer S, Blackman MJ.   +13 more
europepmc   +1 more source

Development and validation of a long-term co-maturation protocol for human stem cell-derived microglia and neuronal networks. [PDF]

Stem Cell Reports
Mordelt A, Schuurmans IME, Scheefhals N, Hommersom MP, Slottje K, Mast K, Graziani M, González CO, Mulder KW, Wingens LJA, Schubert D, Nadif Kasri N, de Witte LD.   +12 more
europepmc   +1 more source

Glycolysis Drives TLR Ligand-Induced Maturation and Immune Activation of Liver Sinusoidal Endothelial Cells. [PDF]

Liver Int
Shu Y, Yan H, Sun H, Gu X, Littwitz-Salomon E, Liu J, Wu J, Yang D, Zheng X, Lu M, Du Y.   +10 more
europepmc   +1 more source