Results 61 to 70 of about 88,012 (264)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Digital Transformation Meets Process Improvement: Driving Enterprise Continuous Efficiency-Seeking
Engineering ProceedingsAutomation and digitization have gained every aspect of our life. Performance and digital are precepted as twins, and thus process improvement (i.e., performance continuous seek) has fatally met digital.
Najib Ouradi, Rajaa Saidi, Walid Cherif
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Recent Trends in Information and Cyber Security Maturity Assessment: A Systematic Literature Review
SystemsThis work represents a comprehensive and systematic literature review (SLR) that follows the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for research assessing information and cyber security maturity. The period
Alenka Brezavšček, Alenka Baggia
doaj +1 more source
Development of a Generic Framework to Assess Asset Management Maturity within Organisations
Tehnički Glasnik, 2021 With the comprehensive Lean Smart Maintenance philosophy and its associated maturity model, organisations were given a tool to reach asset and maintenance excellence. This paper discusses the approach used to transfer the scientifically based methods and
Hans Thomas Maier +2 more
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Environmental Research CommunicationsThis study addresses the absence of a sector-sensitive maturity assessment for circular business models in the Packaging and Containers (P&C) value chain.
David Ramírez-Naranjo +4 more
doaj +1 more source