Results 131 to 140 of about 136,721 (312)

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Digital Maturity Model

, 2022
In Gesellschaften, in denen schnelle Veränderungen und unregelmäßige technologische Veränderungen üblich sind, haben kleine und mittlere Unternehmen (KMU) Schwierigkeiten, mit diesen grundlegenden Veränderungen Schritt zu halten. Verschiedene externe und interne Hürden hindern KMUs daran, die digitale Lücke zwischen ihren eigenen digitalen Initiativen ...
openaire   +1 more source

Maturity models and safety culture: A critical review

, 2018
Anastácio Pinto Gonçalves Filho, Patrick Waterson   +1 more
openalex   +2 more sources

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

A Multi-Criteria Decision-Making Model for Selecting a Maturity Model

, 2023
João Batista Sarmento dos Santos Neto, Ana Paula Cabral Seixas Costa   +1 more
openalex   +2 more sources

A digital business transformation maturity model for micro enterprises in developing countries [PDF]

, 2023
Supattana Sukrat, Atchara Leeraphong
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

A maturity model for Clinical Trials Management Ecosystem. [PDF]

J Clin Transl Sci
Sehgal S, Pua EC, Rojevsky S, Becich MJ, Fehrmann J, Knosp BM, Wilcox A, Talbert JC, Craven CK, Starren J.   +9 more
europepmc   +1 more source