Results 71 to 80 of about 812,357 (299)
A Systematic Review of the Application of Maturity Models in Universities
Information, 2020 A maturity model is a widely used tool in software engineering and has mostly been extended to domains such as education, health, energy, finance, government, and general use.
Esteban Tocto-Cano +3 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Cyber Resilience Progression Model
Applied Sciences, 2020 Due to the hazardous current cyber environment, cyber resilience is more necessary than ever. Companies are exposed to an often-ignored risk of suffering a cyber incident. This places cyber incidents as one of the main risks for companies in the past few
Juan F. Carías +3 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Default and the maturity structure in sovereign bonds [PDF]
This paper studies the maturity composition and the term structure of interest rate spreads of government debt in emerging markets. In the data, when interest rate spreads rise, debt maturity shortens and the spread on short-term bonds is higher than on ...
Ananth Ramanarayanan, Cristina Arellano
core +3 more sources
Investigating Process Maturity Modeling as an Advertising Process Improvement Paradigm
Marketing of Scientific and Research Organizations, 2019 This article examined a variant of the Capability Maturity Model integrated (CMMi) through the lens of advertising process improvement. The population and sample were taken from a national array of U.S. marketing organizations.
Doss Daniel Adrian +3 more
doaj +1 more source
A Metamodel for Evaluating Enterprise Readiness in the Context of Industry 4.0
Information, 2019 This article analyzes the available readiness indexes and maturity models applied for trends designated as “4.0„, with a focus on Industry 4.0, primarily within the countries of Europe. Based upon it, the available indexes and maturity models
Josef Basl, Petr Doucek
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Integrated AI and Innovation Management: The Beginning of a Beautiful Friendship
Technology Innovation Management Review, 2020 There is a growing consensus around the transformative and innovative power of Artificial Intelligence (AI) technology. AI will transform which products are launched and how new business models will be developed to support them.
Nina Bozic Yams +4 more
doaj +1 more source