Results 91 to 100 of about 121,608 (304)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelos de madurez y su idoneidad para aplicar en pequeñas y medianas empresas / Maturity models and the suitability of its application in small and medium enterprises

Revista Científica de Ingeniería Industrial, 2014
Actualmente, existen metodologías, estándares, modelos de madurez y guías que pueden ayudar a una organización a mejorar su modo de operar. Los modelos de madurez constituyen una evolución de las metodologías para gestionar la calidad de la ...
Elizabeth Pérez-Mergarejo, Ileana Pérez-Vergara, Yordán Rodríguez-Ruíz   +2 more
doaj  

Virtual World Platforms: A Comparative Analysis of Quality According to ISO 25010 Standards and Maturity Models

Virtual Worlds
The rapid proliferation of metaverse platforms with heterogeneous architectures, functionalities, and purposes poses a significant challenge for informed technology selection. Consequently, there is a need for structured evaluation approaches that enable
Fabiola Sáez-Delgado, Javier Mella-Norambuena, Paulo Coronado, Yaranay López-Angulo, Guillermo Ramírez, María Badilla-Quintana, Andrés Chiappe   +6 more
doaj   +1 more source

Digital health and capability maturity models-a critical thematic review and conceptual synthesis of the literature. [PDF]

J Am Med Inform Assoc, 2023
Liaw ST, Godinho MA.
europepmc   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Industry 4.0/5.0 Maturity Models: Empirical Validation, Sectoral Scope, and Applicability to Emerging Economies

Systems
This article presents an academic literature analysis of 75 Industry 4.0 (I4.0) and Industry 5.0 (I5.0) maturity models published between 2020 and 2024, examining their empirical validation, sectoral scope, geographical origin, and stated applicability ...
Dayron Reyes Domínguez, Marta Beatriz Infante Abreu, Aurica Luminita Parv   +2 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Which one? A suggested approach for evaluating digital health maturity models. [PDF]

Front Digit Health, 2022
Woods L, Eden R, Duncan R, Kodiyattu Z, Macklin S, Sullivan C.   +5 more
europepmc   +1 more source

Maturity Models in IS Research

, 2010
Notwithstanding the relevance of maturity assessments in practice, Information Systems (IS) research has – despite exceptions – yet rarely endeavoured into reflecting and developing theoretically sound maturity models.
Poeppelbuss, Jens, Becker, Joerg, Simons, Alexander, Niehaves, Bjoern   +3 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source