Results 71 to 80 of about 121,608 (304)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Debt maturity, risk, and asymmetric information [PDF]

We test the implications of Flannery’s (1986) and Diamond’s (1991) models concerning the effects of risk and asymmetric information in determining debt maturity, and we examine the overall importance of informational asymmetries in debt maturity choices.
Marco A. Espinosa-Vega, Nathan H. Miller, Allen N. Berger, W. Scott Frame   +3 more
core  

Maturity, indebtedness, and default risk [PDF]

In this paper, the authors advance the theory and computation of Eaton-Gersovitz style models of sovereign debt by incorporating long-term debt and proving the existence of an equilibrium price function with the property that the interest rate on debt is
Satyajit Chatterjee, Burcu Eyigungor
core   +4 more sources

Advancing maturity modeling for precision oncology

Journal of Clinical and Translational Science
Introduction: This study aimed to map the maturity of precision oncology as an example of a Learning Health System by understanding the current state of practice, tools and informatics, and barriers and facilitators of maturity.
Ariella Hoffman-Peterson, Megh Marathe, Mark S. Ackerman, William Barnett, Reema Hamasha, April Kang, Kashmira Sawant, Allen Flynn, Jodyn E. Platt   +8 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Critical Evaluation of and Proposed Corrections for Knowledge Management Maturity Models

, 2018
Presentation for the 2018 International Conference on Knowledge Managment. This presentation reports on a comprehensive root cause analysis exercise of deficiencies in knowledge management maturity ...
Pierre, Shaqueta, Kollinger, Justin, Bedford, Denise A. D., Testa, Dean   +3 more
core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Evolving Maturity Models for Electric Power System Cybersecurity: A Case-Driven Framework Gap Analysis

Applied Sciences
The electric power grid constitutes a foundational pillar of modern critical infrastructure (CI), underpinning societal functionality and global economic stability. Yet, the increasing convergence of Information Technology (IT) and Operational Technology
Akın Aytekin, Aysun Coşkun, Mahir Dursun   +2 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source