Results 121 to 130 of about 100,072 (310)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Digital Maturity Model

open access: yes, 2022
In Gesellschaften, in denen schnelle Veränderungen und unregelmäßige technologische Veränderungen üblich sind, haben kleine und mittlere Unternehmen (KMU) Schwierigkeiten, mit diesen grundlegenden Veränderungen Schritt zu halten. Verschiedene externe und interne Hürden hindern KMUs daran, die digitale Lücke zwischen ihren eigenen digitalen Initiativen ...
openaire   +1 more source

Maturity models and safety culture: A critical review

open access: green, 2018
Anastácio Pinto Gonçalves Filho   +1 more
openalex   +2 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

open access: yesFEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko   +2 more
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

open access: yesFEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

A Multi-Criteria Decision-Making Model for Selecting a Maturity Model

open access: hybrid, 2023
João Batista Sarmento dos Santos Neto   +1 more
openalex   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

A measurement framework to assess software maturity models. [PDF]

open access: yesPeerJ Comput Sci
Alshareef R   +3 more
europepmc   +1 more source

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