Results 101 to 110 of about 268,996 (308)
Advanced Science, EarlyView.This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma +16 more
wiley +1 more source
Advanced Science, EarlyView.Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan +11 more
wiley +1 more source
And If Your Friends Jumped Off A Bridge, Would You Do It Too? : How Developmental Neuroscience Can Inform Legal Regimes Governing Adolescents [PDF]
, 2015 Legal models of adolescent autonomy and responsibility in various domains of law span a spectrum from categorical prohibitions of certain behaviors to recognitions of total adolescent autonomy.
Pustilnik, Amanda C, Tennison, Michael N
core +1 more source
Advanced Science, EarlyView.A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu +8 more
wiley +1 more source
Ethical Precision in Nanoscale Brain Interfacing
Advanced Science, EarlyView.As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley +1 more source
What do we really know about the constraints and enablers of physical activity levels in young children? [PDF]
, 2002 Ample evidence exists to support the benefits of habitual physical activity levels on long term health and well-being for adults, youth and, more recently, children.
Hands, Beth P +2 more
core +1 more source
Advanced Science, EarlyView.We investigate whether Montessori and traditional schooling systems shape the developmental trajectory of large‐scale brain dynamics in different ways. We quantify the arrow of time (“non‐reversibility”) in neural activity during resting state and movie‐watching, revealing distinct maturational patterns.
Elvira del Agua +6 more
wiley +1 more source
Social maturity - psychological perspective
, 2020 The article is used to explain the criteria for developing a socially mature personality. Nowadays the processes that take place in our society, significantly and in some cases irreversibly affect the life of an individual, and social maturity is an important quality that contributes to optimal functioning of such individual.
openaire +1 more source
Distinct Biotypes of Visual Perception in Major Depressive Disorder
Advanced Science, EarlyView.In a discover dataset (272 acute MDD patients), this work identifies a novel depression biotype characterized by impaired visual motion perception, using machine learning clustering. An independent dataset confirms the robustness of this biotype through cross‐validation and demonstrates its generalizability.
Zhuoran Cai +13 more
wiley +1 more source
STUDY OF EMOTIONAL MATURITY OF UNIVERSITY TEACHERS FROM THE POINT SYSTEMS APPROACH
Вестник Мининского университета, 2017 The article analyzes the phenomenon of emotional maturity from the perspective of various philosophical and psychological approaches (psychoanalytic, existential, humanistic, cognitive, emotional, cultural and historical).
L. V. Tarabakina, T. L. Shabanova
doaj +2 more sources