Results 141 to 150 of about 266,456 (351)
Genome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes
Advanced Science, EarlyView.This study explores genome‐wide by lifetime environment interactions on brain imaging phenotypes. Gene‐environment interactions explain more phenotypic variance than main effects, pinpoint regulatory variants, and reveal exposure‐specific biological pathways.
Sijia Wang +51 more
wiley +1 more source
Advanced Science, EarlyView.In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong +11 more
wiley +1 more source
Ecologically‐Valid Emotion Signatures Enhance Mood Disorder Diagnostics
Advanced Science, EarlyView.This study identifies ecologically‐valid Divergent Emotional Functional Networks (DEFN), derived from dynamic functional connectivity during naturalistic movie watching. The DEFN reliably enhances diagnostic accuracy for mood disorders, including major depressive and bipolar disorders, demonstrating strong reproducibility across demographic factors and
Shuyue Xu +6 more
wiley +1 more source
Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder
Advanced Science, EarlyView.NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai +13 more
wiley +1 more source
Advanced Science, EarlyView.PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao +6 more
wiley +1 more source
Assessing Juvenile Psychopathy: Developmental and Legal Implications [PDF]
, 2006 Psychopath. The word alone evokes powerful emotions and images. Attaching that label to a juvenile offender is a serious charge, and should be done so with caution, especially given that the standard assessment tools for psychopathy were originally ...
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Meikuang AnquanIn order to evaluate miners’ emergency ability reasonably, the evaluation model of miners’ emergency ability maturity was established. Firstly, based on the information processing model of miners’ emergency ability, the information processing process and
Lianhua CHENG +4 more
doaj +1 more source
Interest Term Premiums and C-CAPM: A Test of a Parsimonious Model [PDF]
This paper proposes a consumption-based model that accounts for term premiums of the nominal term structure of interest rates. The driving force behind the model is the looking at the ex ante term premium.
Hubert De La Bruslerie +1 more
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Family Law – Handling a Hague trial: the courts’ perspective [PDF]
, 1998 The authors examine the themes and provisions of the Hague Convention on the Civil Aspects of International Child Abduction, looking at presumption in favour of returning the child, with reference to case law examples. Article by William M.
Bennett, Margaret H., Hilton, William M.
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