Results 151 to 160 of about 542,377 (310)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Polyphenol Composition, Antioxidant Capacity and Xanthine Oxidase Inhibition Mechanism of Furong Plum Fruits at Different Maturity Stages. [PDF]

Foods, 2023
Zheng Z, Wu L, Deng W, Yi K, Li Y.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Transcriptome Studies Reveal the N⁶-Methyladenosine Differences in Testis of Yaks at Juvenile and Sexual Maturity Stages. [PDF]

Animals (Basel), 2023
Guo S, Pei J, Wang X, Cao M, Xiong L, Kang Y, Ding Z, La Y, Chu M, Bao P, Guo X.   +10 more
europepmc   +1 more source

Architectural Adequacy and Evolutionary Adequacy as Characteristics of a Candidate Informational Money [PDF]

, 2015
For money-like informational commodities the notions of architectural adequacy and evolutionary adequacy are proposed as the first two stages of a moneyness maturity hierarchy.
Bergstra, Jan A.
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Exploring the Link Between Calcaneal Apophysis Maturation and Heel Pain in Youth Baseball Players

Orthopaedic Journal of Sports Medicine
Background: Calcaneal apophysitis is the most common cause of heel pain in children and adolescents. However, the relationship between skeletal maturity and heel pain in the specific youth cohort is unclear.
Yuki Honma MS, Toshiharu Tsutsui PhD, RRT, JSPO-AT, Wataru Sakamaki MS, Akina Higuchi MS, RPT, Emi Nakamura PhD, RRT, JSPO-AT, Suguru Torii PhD, MD   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Visualizing the Distribution of Jujube Metabolites at Different Maturity Stages Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging. [PDF]

Foods, 2023
Lu D, Wu Y, Zhang J, Qi Y, Zhang Y, Pan Q.   +5 more
europepmc   +1 more source

Physico-Chemical Changes in Cavendish Banana (Musa Cavendishii L. Var. Montel) During Fruit Development, Maturation and Storage [PDF]

, 1997
Studies on the physico-chemical changes between different hand positions (top, middle and bottom) within a bunch and different finger positions (upper and lower) within a hand at different maturity stages (between 3 to 15 weeks from the appearance of ...
Mustaffa, Razali
core