Results 71 to 80 of about 492,566 (255)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Satisfiability for two-variable logic with two successor relations on finite linear orders

, 2013
We study the finitary satisfiability problem for first order logic with two variables and two binary relations, corresponding to the induced successor relations of two finite linear orders.
Figueira, Diego
core  

Sparse Representation Classification Beyond L1 Minimization and the Subspace Assumption

, 2020
The sparse representation classifier (SRC) has been utilized in various classification problems, which makes use of L1 minimization and works well for image recognition satisfying a subspace assumption.
Chen, Li, Dong, Yuexiao, Priebe, Carey E., Shen, Cencheng   +3 more
core  

Block Copolymer at Nano-Patterned Surfaces

, 2012
We present numerical calculations of lamellar phases of block copolymers at patterned surfaces. We model symmetric di-block copolymer films forming lamellar phases and the effect of geometrical and chemical surface patterning on the alignment and ...
Bita I., Böker A., Ceniceros H. D., Cheng J. Y., Cheng J. Y., Geisinger T., Ham S. J., Hamley I. W., Kielhom L., Kim S., Kim S. O., Li H. W., Li M., Li R. R., Lin C.-Y., Lin C.-Y., Liu P.-H., Lopes W. A., Man X. K., Mansky P., Matsen M. W., Matsen M. W., Matsen M. W., Park C., Park M., Park S., Pereira G. G., Pereira G. G., Pereira G. G., Petera D., Ruiz R., Ryu D. Y., Segalman R. A., Semenov A. N., Stoykovich M. P., Stoykovich M. P., Sundrani D., Tsori Y., Tsori Y., Tsori Y., Tsori Y., Tsori Y., Tsori Y., Tsori Y., Yang X. M.   +44 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Identification of intracellular calcium pools. Selective modification by thapsigargin.

Journal of Biological Chemistry, 1991
Recent studies have identified inositol 1,4,5-tris-phosphate(InsP3)-sensitive and -insensitive Ca2+ pools and a GTP-dependent mechanism that transfers Ca2+ between them.
J. Bian, T. K. Ghosh, J. Wang, D. Gill
semanticscholar   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Muonium-antimuonium conversion in models with heavy neutrinos

, 2005
We study muonium-antimuonium conversion and mu+ e- to mu- e+ scattering within two different lepton-flavor-violating models with heavy neutrinos: model I is a typical seesaw that violates lepton number as well as flavor; model II has a neutrino mass ...
B. Kayser, B. Pontecorvo, C. S. Kim, Claudio O. Dib, Gorazd Cvetič, J. D. Kim, L. Willmann   +6 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source