Results 51 to 60 of about 282,015 (284)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Optimizing Ambulance Allocation in Dynamic Urban Environments: A Historic Data-Driven Approach

Applied Sciences, 2023
In this study, we present a methodology to solve the multi-period ambulance relocation problem based on historical data. We present a methodology to convert historical data in latitude–longitude coordinates into cell-based network data.
Seongho Kang, Taesu Cheong
doaj   +1 more source

On the fuzzy maximal covering location problem [PDF]

European Journal of Operational Research, 2020
In this paper studies the maximal covering location problem, assuming imprecise knowledge of all data involved. The considered problem is modeled from a fuzzy perspective producing suitable fuzzy Pareto solutions. Some properties of the fuzzy model are studied, which validate the equivalent mixed-binary linear multiobjective formulation proposed.
Arana, Manuel, Blanco, Víctor, Fernández, Elena   +2 more
openaire   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Function of One Regular Separable Relation Set Decided for the Minimal Covering in Multiple Valued Logic

MATEC Web of Conferences, 2016
Multiple-valued logic is an important branch of the computer science and technology. Multiple-valued logic studies the theory, multiple-valued circuit & multiple-valued system, and the applications of multiple-valued logic included.In the theory of ...
Liu Yu Zhen, Liu Min, Liu Xing Bao, Zhang Xin Fen   +3 more
doaj   +1 more source

Maximal Independent Sets and Separating Covers

The American Mathematical Monthly, 2011
In 1973, Katona raised the problem of determining the maximum number of subsets in a separating cover on n elements. The answer to Katona's question turns out to be the inverse to the answer to a much simpler question: what is the largest integer which is the product of positive integers with sum n?
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Norm inequalities for maximal operators

Journal of Inequalities and Applications, 2022
In this paper, we introduce a family of one-dimensional maximal operators M κ , m $\mathscr{M}_{\kappa ,m}$ , κ ≥ 0 $\kappa \geq 0$ and m ∈ N ∖ { 0 } $m\in \mathbb{N}\setminus \{0\}$ , which includes the Hardy–Littlewood maximal operator as a special ...
Salem Ben Said, Selma Negzaoui
doaj   +1 more source

The fixed charge maximal covering location problem

Papers in Regional Science, 1992
The maximal covering location problem is based on locatingp facilities in such a manner that coverage is maximized within set distance or time standards. This problem has been extended in a number of different ways where the main theme still involves locating a fixed number of facilities.
Richard L. Church, Rhonda R. Davis
openaire   +1 more source