Results 71 to 80 of about 282,015 (284)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

ReCovNet: Reinforcement learning with covering information for solving maximal coverage billboards location problem

International Journal of Applied Earth Observations and Geoinformation
Maximizing billboard coverage with limited resources and different objective goals plays a vital role in social activities. The Maximal Coverage Billboard Location Problem (MCBLP) is complex, especially for multi-objective functions.
Yang Zhong, Shaohua Wang, Haojian Liang, Zhenbo Wang, Xueyan Zhang, Xi Chen, Cheng Su   +6 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

A New Heuristic Solution Method for Maximal Covering Location-Allocation Problem with M/M/1 Queueing System [PDF]

Journal of Sciences, Islamic Republic of Iran, 2012
We consider the queueing maximal covering location-allocation problem (QM-CLAP) with an M/M/1 queueing system. We propose a new solution procedure based on decomposition of the problem into smaller sub-problems.
F. Moeen Moghadas
doaj  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

On the Semigroup Whose Elements Are Subgraphs of a Complete Graph

Mathematics, 2018
Let K n be a complete graph on n vertices. Denote by S K n the set of all subgraphs of K n . For each G , H ∈ S K n , the ring sum of G and H is a graph whose vertex set is V ( G ) ∪ V ( H ) and whose edges are ...
Yanisa Chaiya, Chollawat Pookpienlert, Nuttawoot Nupo, Sayan Panma   +3 more
doaj   +1 more source

The space of complete embedded maximal surfaces with isolated singularities in the 3-dimensional Lorentz-Minkowski space $\l^3$

, 2005
We show that a complete embedded maximal surface in the 3-dimensional Lorentz-Minkowski space $L^3$ with a finite number of singularities is, up to a Lorentzian isometry, an entire graph over any spacelike plane asymptotic to a vertical half catenoid or ...
Fernandez, Isabel, Lopez, Francisco J., Souam, Rabah   +2 more
core   +1 more source

Topologically maximal convergences, accessibility, and covering maps [PDF]

Mathematica Bohemica, 1998
Summary: Topologically maximal pretopologies, paratopologies and pseudotopologies are characterized in terms of various accessibility properties. Thanks to recent convergence-theoretic descriptions of miscellaneous quotient maps (in terms of topological, pretopological, paratopological and pseudotopological projections), the quotient characterizations ...
Dolecki, Szymon, Pillot, Michel
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Efficient Solution Procedure to Develop Maximal Covering Location Problem Under Uncertainty (Using GA and Simulation)

International Journal of Industrial Engineering and Production Research, 2008
In this paper, we present the stochastic version of Maximal Covering Location Problem which optimizes both location and allocation decisions, concurrently. It’s assumed that traveling time between customers and distribution centers (DCs) is uncertain and
K. Shahanaghi, V.R. Ghezavati
doaj