Results 71 to 80 of about 290,738 (260)

Herb drug interaction: effect of Manix® on pharmacokinetic parameters of pefloxacin in rat model

open access: yesAsian Pacific Journal of Tropical Biomedicine, 2014
Objective: To evaluate the effect of Manix®, the commonly used polyherbal formulation on pefloxacin pharmacokinetic parameters. Methods: Microbiological assay was employed using clinical isolate of Escherichia coli samples from hospitalized patients ...
Nduka Sunday Odunke   +4 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Effects of all‐out sprint interval training under hyperoxia on exercise performance

open access: yesPhysiological Reports, 2019
All‐out sprint interval training (SIT) is speculated to be an effective and time‐efficient training regimen to improve the performance of aerobic and anaerobic exercises.
Michihiro Kon   +2 more
doaj   +1 more source

Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD

open access: yesRespiratory Research, 2023
Background Parameters from maximal expiratory flow-volume curves (MEFVC) have been linked to CT-based parameters of COPD. However, the association between MEFVC shape and phenotypes like emphysema, small airways disease (SAD) and bronchial wall ...
Kenneth Verstraete   +11 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Maximal hyperelliptic curves of genus three

open access: yesFinite Fields and Their Applications, 2009
This paper concerns maximal hyperelliptic curves of genus 3 (and in part also genus 5 and 6), where `maximal' means attaining the upper Hasse-Weil-Serre bound. It gives an overview of which fields were known to (dis)allow for such curves and proceeds by proving new results.
Kodama, Tetsuo   +2 more
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Bring's Curve: its Period Matrix and the Vector of Riemann Constants

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2012
Bring's curve is the genus 4 Riemann surface with automorphism group of maximal size, S_5. Riera and Rodríguez have provided the most detailed study of the curve thus far via a hyperbolic model.
Harry W. Braden, Timothy P. Northover
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

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