Results 151 to 160 of about 4,214 (224)

Beyond Upper Airway Involvement: Evidence of Intrinsic Lung Disease in a Mouse Model of Mucopolysaccharidosis I. [PDF]

J Inherit Metab Dis
Donnelley M, Smith R, Cmielewski P, Reyne N, Pirakalathanan P, Eikelis N, Nilsen K, Louise J, Barratt K, Logan J, Ung B, Parsons D, Brooks D, Orgeig S, Parkinson-Lawrence E.   +14 more
europepmc   +1 more source

Variant Class–Specific Phenotypes and Outcomes in Pediatric TBX4‐Associated Pulmonary Hypertension

Pediatric Pulmonology, Volume 61, Issue 10, October 2026.
ABSTRACT Aim To describe the variant class associations with phenotype, natural history, treatment response, and outcomes in children with TBX4‐associated pulmonary hypertension (TBX4‐PH). Methods Retrospective cohort analysis of children < 18 years referred to the National Paediatric Pulmonary Hypertension Service between 2001 and 2025. Results Twenty‐
Cara Morgan, Alistair Calder, Matina Prapa, Thivya Sekar, Andrew Constantine, Tomas Woodgate, Annabelle Barnes, Eimear McGovern, Paul Aurora, Rossa Brugha, Sadia Quyam, Andrew Bush, Shahin Moledina   +12 more
wiley   +1 more source

Association of Mobilization and Chest Physiotherapy on Weaning Outcome of Prolonged Weaning Subjects: A Retrospective Cohort

Physiotherapy Research International, Volume 31, Issue 4, October 2026.
ABSTRACT Background and Purpose Prolonged weaning—characterized by failure in three consecutive spontaneous breathing trials (SBTs) and requiring over 7 days of mechanical ventilation post‐initial SBT—presents a critical clinical challenge often exacerbated by intensive care unit‐acquired weakness (ICU‐AW) and impaired airway clearance.
Tsung‐Hsien Wang, Ying‐Po Hsu, Cheng‐Shin Tsai   +2 more
wiley   +1 more source

Concavity of the maximal expiratory flow-volume curve, and incidence of COPD and respiratory symptoms: a population-based cohort study. [PDF]

ERJ Open Res
Tan DJ, Johns DP, Lodge CJ, Bui DS, Vicendese D, Hamilton GS, Han MK, Agusti A, Abramson MJ, Perret JL, Dharmage SC, Walters EH.   +11 more
europepmc   +1 more source

Dynamic Prediction of Clinical Endpoints in Survival Analysis With Machine and Deep Learning: A Systematic Review and Regulatory Perspective

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Accurate prediction of time‐to‐event outcomes is essential for clinical decision‐making and model‐informed drug development (MIDD). Conventional survival models may inadequately represent complex longitudinal patient trajectories, time‐dependent treatments, and evolving biomarker or pharmacokinetic/pharmacodynamic (PK/PD) profiles.
Xinyi Liu, Shuai Shao, Dorothee Semiond, Malidi Ahamadi   +3 more
wiley   +1 more source

Early predictors of persistent childhood asthma and allergic rhinitis: A machine learning study using post‐hoc explainability [PDF]

Pediatr Allergy Immunol
Machine learning models applied to detailed early‐life data showed limited ability to predict which children developed persistent asthma or allergic rhinitis. Although clinically plausible features contributed to predictions, model performance was insufficient for reliable individual prognostic stratification.
Skov F, Lovrić M, Sultan T, Bønnelykke K, Chawes B, Stokholm J, Thorsen J, Rasmussen M, Schoos A.   +8 more
europepmc   +2 more sources

Dynamic hyperinflation occurs in healthy subjects during maximal voluntary ventilation. [PDF]

Front Med (Lausanne)
Herpeux A, Pauwen NY, Sergysels R, Peeters A, Ninane V, Bruyneel M.   +5 more
europepmc   +1 more source

Positive end-expiratory pressure in pediatric acute respiratory distress syndrome: a narrative review. [PDF]

Transl Pediatr
Allen L, Mallory P, Rotta AT, Rehder KJ, Miller AG.   +4 more
europepmc   +1 more source

Pre‐operative three‐dimensional face scans for predicting difficult facemask ventilation: a prospective development study

Anaesthesia, Volume 81, Issue 10, Page 1340-1348, October 2026.
Summary Introduction Facemask ventilation is a key airway management skill but predicting difficulty can be challenging. Pre‐operative three‐dimensional face scanning may have diagnostic value. We aimed to identify interpretable facial shape features and to quantify their value for predicting difficult facemask ventilation.
Viktor A. Wünsch, Hannes Bommes, Sofia Germer, Milan Piltan, Philipp Breitfeld, Sarah Latus, Linda Krause, Christian Zöllner, Christopher Gundler, Martin Petzoldt   +9 more
wiley   +1 more source

Development and validation of a multimodal risk prediction model for early COPD progression: a retrospective study integrating clinical, functional, and CT radiomic features. [PDF]

Ther Adv Respir Dis
Zhang J, Yang Q, Dai S, Li J, Zhang Z, Jia Z, Zhu W, Yang R, Bai X, Li W, Zhang X, Zhang X, Chen J, Zou W.   +13 more
europepmc   +1 more source