Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon +3 more
wiley +1 more source
How to quickly determine whether patients with chronic cough need corticosteroid treatment--construction of a predictive model for corticosteroid-responsive cough in chronic cough. [PDF]
Yi B +7 more
europepmc +1 more source
How Does Progressivity Affect the Tax Cut Multiplier?
ABSTRACT How does the targeting of personal income tax cuts affect the output multiplier? This paper provides quantitative evidence using a heterogeneous‐agent New‐Keynesian model calibrated to match US distributions of income, wealth, marginal tax rates, and marginal propensities to consume.
Christian Gillitzer
wiley +1 more source
The invasive and non-invasive monitoring of inspiratory effort and drive during assisted mechanical ventilation. [PDF]
Chiumello D +3 more
europepmc +1 more source
ABSTRACT The importance of sleep as a key component of cardiovascular health has been increasingly recognized. Our previous research demonstrated that auditory‐enhanced slow waves increase cardiac function, but the underlying mechanisms behind these beneficial effects remain uncertain. In this study, we examined the influence of two types of slow waves
Giulia Alessandrelli +16 more
wiley +1 more source
Feasibility and results of joint ambulatory monitoring of exposure to particulate matter pollution and lung function in children in Abidjan, Côte d'Ivoire: a cross-sectional observational study. [PDF]
Pajot A +10 more
europepmc +1 more source
Integrating Preoperative Preserved Ratio Impaired Spirometry and Inflammatory Markers to Predict Postoperative Complications and Survival in Esophageal Squamous Cell Carcinoma After Neoadjuvant Therapy. [PDF]
Xie Q +7 more
europepmc +1 more source
ABSTRACT Sodium bicarbonate (SB) ingestion may improve high‐intensity exercise performance in efforts that range from 1 to 60 min; however, to date, no studies have investigated the effects of SB supplementation during exercise, nor its potential to attenuate the fatigue‐induced decline in parameters of the power‐duration curve during prolonged ...
Bernardo R. Norte +11 more
wiley +1 more source
Allergy burden score and lung function impairment in children with asthma: a dose-response cross-sectional study. [PDF]
Zhao J +5 more
europepmc +1 more source

