Results 231 to 240 of about 69,010 (290)

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Tissue-specific mitochondrial pathway remodeling linked to longevity in honeybee queens. [PDF]

PLoS One
Chevret CJL, Echegaray JF, Walton A, Lo M, Rueppell O, Lemieux H.   +5 more
europepmc   +1 more source

Universal Solvent Escape Strategies for Efficient Curing of Hydrogen‐Bond‐Rich 3D Printing Inks

Advanced Science, EarlyView.
This study developed a new 3D printing method for hydrogen‐bonded polymers by combining solvent replacement, nanoparticles, and optimized printing paths. This allows fast, precise scaffold fabrication. The scaffolds can be easily customized and release therapeutic agents slowly through protonation, enabling personalized bone, blood vessel, and nerve ...
Jie Chen, Qing Zhao, Wentao Fu, Weixian Chen, Xiaoqian Zhang, Gaiying Ye, Qinglei Meng, Liyuan Shao, Qian Ma, Lin Zhao, Ying Zhao, Weihua Guo   +11 more
wiley   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Divergent Changes in Peak Fat Oxidation and Fat_max Following 3-Day Dietary Interventions Are Related to Muscle Glycogen Availability in Men. [PDF]

Scand J Med Sci Sports
Tarry EK, Vestergaard SG, Petersen EA, Olsen MC, Hansen M, Ingersen A, Connor T, Pilegaard H, Dela F, Larsen S, Shaw CS, Helge JW.   +11 more
europepmc   +1 more source

Submaximal Exercise Testing for Metabolic Flexibility: A Possible Window Into Mitochondrial Function. [PDF]

AJPM Focus
Lovell DI, Stuelcken M, Eagles A.
europepmc   +1 more source

Consensus Document of the Spanish Nutrition Society (SEÑ) on Nutritional Strategies in Sports. [PDF]

Nutrients
Mielgo-Ayuso J, Macho-González A, Úbeda N, Sánchez-Oliver AJ, Martínez-Ferrán M, Fernández-Lázaro D, Aparicio-Ugarriza R, Roche E, González-Gross M.   +8 more
europepmc   +1 more source

Successfully Reducing Sitting Time Can Improve Metabolic Flexibility. [PDF]

Scand J Med Sci Sports
Garthwaite T, Sjöros T, Laine S, Koivumäki M, Vähä-Ypyä H, Norha J, Kallio P, Saarenhovi M, Löyttyniemi E, Sievänen H, Houttu N, Laitinen K, Kalliokoski KK, Vasankari T, Knuuti J, Heinonen I.   +15 more
europepmc   +1 more source

Effects of short-term sleep reduction and aerobic exercise on metabolism and inflammation in healthy adults. [PDF]

Curr Res Physiol
Dupuis GL, Kaveney J, Lessard E, Wilson B, McGinnis GR, Perkins RK.   +5 more
europepmc   +1 more source