Results 41 to 50 of about 86,151 (303)

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

open access: yesFEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modeling longitudinal changes in maximal-intensity exercise performance in young male rowing athletes. [PDF]

open access: yes, 2012
The purpose of the current study was to examine the effect of age and body size upon maximal-intensity exercise performance in young rowing athletes. Male participants (n = 171) aged 12-18 years were assessed using an "all-out" 30-s rowing ergometer test,
Markovic, Goran   +3 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Reliability and validity of the Chester treadmill walk test for the prediction of aerobic capacity [PDF]

open access: yes, 2009
The aim of this dissertaion is to assess the validity and reliability of the Chester Treadmill Walk test (CTWT) for the prediction of aerobic capacity.
McGuigan, Ross A.
core  

Oxygen uptake efficiency slope (oues) calculated at submaximal intensities is related to mortality in apparently healthy adults from the Ball St cohort

open access: yes, 2022
Access to thesis permanently restricted to Ball State community onlyThe purpose of this study was to determine the relationship between submaximal oxygen uptake efficiency slope derived from a maximal test and all-cause mortality in apparently healthy ...
Novelli, Dominic
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

O efeito da intensidade do exercício prévio sobre a cinética do consumo de oxigênio durante a corrida [PDF]

open access: yes, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Desportos, Programa de Pós-Graduação em Educação Física, Florianópolis, 2014.Abstract : The oxygen uptake (VO2) measured at pulmonary level reflects changes in oxidative ...
Nascimento, Paulo Cesar do
core  

Maximal physiological responses to deep and shallow water running.

open access: yes, 2007
The maximal physiological responses to treadmill running (TMR), shallow water running (SWR) and deep water running (DWR) while wearing a buoyancy vest were compared in 15 trained male runners.
Reilly, Thomas   +3 more
core   +1 more source

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