Results 41 to 50 of about 78,266 (261)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Agreement analysis between critical power and intensity corresponding to 50% in cycling exercise

Revista Brasileira de Cineantropometria e Desempenho Humano, 2016
The purpose of this study was to determine the level of agreement between critical power (CP) and intensity corresponding to 50% of the difference (50% Δ) between oxygen uptake (VO2) at lactate threshold (LT) and maximal oxygen uptake (VO2max) in ...
Kristopher Mendes de Souza, Ricardo Dantas de Lucas, Paulo Cesar do Nascimento Salvador, Lucas Crescenti Abdalla Saad Helal, Luiz Guilherme Antonacci Guglielmo, Camila Coelho Greco, Benedito Sérgio Denadai   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Cardiovascular fitness of forensic psychiatric patients: a longitudinal clinical study

Annals of General Psychiatry
Background Forensic psychiatric patients have a reduced life expectancy, largely due to cardiovascular diseases. Low maximal oxygen uptake is a risk factor for cardiovascular diseases in the general population and may also be essential to the ...
Anja Fernqvist, Peter Andiné, Roland Thomeé, Alessio Degl’Innocenti, Thomas Nilsson, Annelie Gutke   +5 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Evaluation of strength, agility and aerobic capacity in Brazilian football players

Biomedical Human Kinetics, 2018
Study aim: To evaluate the levels of strength, agility and the maximal oxygen uptake (VO2max) between the offensive and de­fensive teams of football players.
Raymundo Ana Carolina Gago, Pernambuco Carlos Soares, de Oliveira Brum Rosana Dias, Castro Juliana Brandão Pinto de, de Oliveira Flávio Boechat, da Gama Dirceu Ribeiro Nogueira, de Alkmim Moreira Nunes Rodolfo, de Souza Vale Rodrigo Gomes   +7 more
doaj   +1 more source

Single and Especially Multisport Participation May Increase Physical Fitness in Younger Americans

Sports, 2022
Background: We sought to examine the associations between sports participation and physical fitness in younger Americans. Methods: The analytic sample included 1108 Americans aged 6–15 years.
Jenny Linker, Bradford Strand, Joe Deutsch, Seungmin Kang, Kelsey Slater, Alaina Driscoll, Ryan McGrath   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source